Coefficients | Statistics | ||||||
---|---|---|---|---|---|---|---|
Brain region; factor | β | T | p value | R2 | F | p value | |
Left hippocampus | Ftotal = 6.3 | < 0.001 | |||||
Diagnosis | −0.05 | −0.47 | 0.64 | ||||
Age | −0.15 | −1.5 | 0.13 | 0.13 | F3,79 = 4.0 | 0.010 | |
Sex | −0.18 | −1.7 | 0.08 | ||||
Maltreatment | −0.37 | −3.4 | 0.001 | 0.113 | F1,78 = 11.6 | < 0.001 | |
Right hippocampus | Ftotal = 6.0 | < 0.001 | |||||
Diagnosis | −0.13 | −1.2 | 0.23 | ||||
Age | −0.002 | −0.02 | 0.99 | 0.08 | F3,79 = 2.3 | 0.08 | |
Sex | −0.18 | −1.7 | 0.09 | ||||
Maltreatment | −0.44 | −4.0 | < 0.001 | 0.154 | F1,78 = 15.7 | < 0.001 | |
Left DMPFC | Ftotal = 15.4 | < 0.001 | |||||
Diagnosis | 0.33 | 3.7 | < 0.001 | ||||
Age | −0.55 | −6.2 | < 0.001 | 0.40 | F3,79 = 17.2 | < 0.001 | |
Sex | −0.18 | −2.0 | 0.048 | ||||
Maltreatment | 0.24 | 2.5 | 0.013 | 0.046 | F1,78 = 6.4 | 0.013 | |
Right DMPFC | Ftotal = 9.4 | < 0.001 | |||||
Diagnosis | 0.14 | 1.4 | 0.16 | ||||
Age | −0.52 | −5.4 | < 0.001 | 0.24 | F3,79 = 8.1 | < 0.001 | |
Sex | −0.16 | −1.6 | 0.11 | ||||
Maltreatment | 0.33 | 3.2 | 0.002 | 0.089 | F1,78 = 10.3 | 0.002 | |
Left OFC | Ftotal = 22.2 | < 0.001 | |||||
Diagnosis | 0.27 | 3.2 | 0.002 | ||||
Age | −0.60 | −7.5 | < 0.001 | 0.45 | F3,79 = 21.4 | <0.001 | |
Sex | −0.33 | −4.1 | < 0.001 | ||||
Maltreatment | 0.32 | 3.7 | < 0.001 | 0.084 | F1,78 = 14.0 | < 0.001 | |
Right OFC | Ftotal = 9.7 | < 0.001 | |||||
Diagnosis | 0.31 | 3.1 | 0.002 | ||||
Age | −0.43 | −4.3 | < 0.001 | 0.33 | F2,79 = 12.8 | < 0.001 | |
Sex | −0.21 | −2.1 | 0.043 | ||||
Maltreatment | 0.08 | 0.76 | 0.45 | 0.005 | F1,78 = 0.6 | 0.45 |
DMPFC = dorsomedial prefrontal cortex; OFC = orbitofrontal cortex.
↵* Results from the regression analysis with diagnosis, age and sex entered as independent variables in a first model and grey matter volumes as dependent variables. Childhood maltreatment was entered in a second step to see whether it would further influence variance in addition to the factors age, sex or diagnosis. Depicted are coefficients and statistics of change. A positive association between brain volume and diagnosis indicates smaller volumes in patients.