Table 2

Mean percentage of fibres projecting from the ALIC to the left MFC, OFC and thalamus in patients with MDD with and without a history of suicide attempts and healthy controls

Between-group t tests; p value
Brain regionF*p valueSuicide attempt < controlNo suicide attempt < controlSuicide attempt < no suicide attempt
Left MFC6.0390.004†0.001†0.049†0.10
Left OFC12.7350.001†0.001†0.006†0.009†
Left thalamus11.1070.001†0.001†0.022†0.006†

  • ALIC = anterior limb of the internal capsule, MDD = major depressive disorder; MFC = medial frontal cortex; OFC = orbitofrontal cortex.

  • ↵* Analysis of covariance.

  • ↵† 2-tailed.