Table 1

Peak amygdala and IFG activation of the interaction between treatment and affective experience

				Peak voxel (MNI)

Group contrast; region	k	Peak t value^*	p value^‡	x	y	z
Interaction effect
Right IFG	283	7.91^†	< 0.001	38	52	0
		4.75^†	0.010	40	40	4
		4.21^†	0.016	38	44	−12
		4.15^†	0.017	42	44	−10
Left amygdala	50	5.18^†	0.006	−20	2	−16
		4.79^†	0.009	−20	−4	−18
Positive pictures
Escitalopram > placebo
Left amygdala	56	2.24	0.013	−20	0	−16
		1.95	0.025	−22	−4	−22
Placebo > escitalopram
Right IFG	48	2.39	0.009	48	42	0
Left IFG	29	2.05	0.021	−44	40	−4
Negative pictures
Escitalopram > placebo
Right IFG	349	3.05	0.001	40	54	2
		2.49	0.007	48	54	2
		2.43	0.008	44	42	2
		2.35	0.010	48	46	10
Left IFG	115	2.60	0.005	−44	48	8
		2.31	0.011	−40	44	−4
Placebo > escitalopram
Left amygdala	104	4.42	0.006^§	−26	−2	−12
		4.33	0.007^§	−26	2	−16
Right amygdala	109	3.13	0.001	24	2	−12
		3.07	0.001	24	4	−16
Neutral pictures
Escitalopram > placebo
Left IFG	105	2.90	0.002	−38	30	−2
Left IFG	70	2.45	0.008	−36	10	12
		2.14	0.017	−42	8	6
Placebo > escitalopram
Right IFG	56	2.63	0.005	58	24	30
		2.17	0.015	56	16	28
		2.00	0.023	50	20	24
		1.87	0.031	48	24	24
Right IFG	30	1.96	0.025	48	40	14
		1.96	0.026	48	38	18
		1.86	0.032	40	40	8
		1.81	0.035	44	44	8
		1.89	0.030	42	46	−6
		1.89	0.030	42	44	−12
		1.89	0.030	38	50	0
		1.84	0.033	42	50	−2

IFG = inferior frontal gyrus; MNI = Montreal Neurological Institute.
↵* Unless otherwise indicated.
↵† F_2,210 statistic value.
↵‡ Partial volume, uncorrected p value, k = 20, unless otherwise indicated.
↵§ Partial volume, false-discovery rate–corrected p value.