Table 1

Enrichment analyses of the genes/mRNAs predicted to be targets of human and mouse miR-137 using the DIANA tool^*

Functional gene category	p value^†	No. of genes
Human miR-137 putative targets
Biological functions
Cancer	< 0.001	531
Organismal death	< 0.001	238
Size of body	< 0.001	98
Movement disorders	< 0.001	117
Locomotion	< 0.001	45
Neuritogenesis	< 0.001	58
Learning	< 0.001	51
Epilepsy	< 0.001	40
Action potential of neurons	< 0.001	22
Chorea	< 0.001	72
Canonical pathways
PAK signalling	0.002	16
Protein kinase A signalling	0.003	39
Ephrin receptor signalling	0.006	22
Paxillin signalling	0.008	15
Agrin Interactions at neuromuscular junction	0.008	12
Cardiac β-adrenergic signalling	0.009	18
D-myo-inositol-5-phosphate metabolism	0.009	18
SAPK/JNK signalling	0.009	14
Glucocorticoid receptor signalling	0.009	27
Sertoli cell-sertoli cell junction signalling	0.009	21
Mouse miR-137 putative targets
Biological functions
Organismal death	< 0.001	200
Cancer	< 0.001	410
Size of body	< 0.001	84
Development of muscle	< 0.001	43
Neurotransmission	< 0.001	46
Development of digestive system	< 0.001	39
Locomotion	< 0.001	37
Action potential of neurons	< 0.001	19
Morphogenesis of embryonic limb	< 0.001	15
Morphogenesis of forelimb	< 0.001	9
Canonical pathways
Paxillin signalling	< 0.001	17
PAK signalling	< 0.001	16
Agrin Interactions at neuromuscular junction	< 0.001	12
Ephrin receptor signalling	0.003	18
Axonal guidance signalling	0.003	34
Glucocorticoid receptor signalling	0.004	24
Ephrin A signalling	0.004	9
Rac signalling	0.006	13
Protein kinase A signalling	0.006	30
Sertoli cell-sertoli cell junction signalling	0.006	18

JNK = jun amino-terminal kinases; PAK = p21-activated kinases; SAPK = stress-activated protein kinases.
↵* The top 10 enriched gene categories for biological functions and canonical pathways (from the Ingenuity tool, www.ingenuity.com) are shown (see Methods). All categories that are directly related to the (normal) development and/or function of the nervous system are underlined.
↵† Significance was determined from a single test p value calculated using the right-tailed Fisher exact test and taking into consideration both the total number of molecules from the analyzed data set and the total number of molecules linked to the same gene category according to the Ingenuity Knowledge Base. Adjusted significance was determined from multiple test–corrected p values using the Benjamini–Hochberg correction (only categories reaching a corrected statistical significance of p < 0.05 are shown).