Table 2

Fourteen putative miR-137 target genes upregulated by enriched environment in the rat barrel cortex

		Microarray analysis		DIANA scores		miRWalk score

Gene^*	Gene description	Fold change	SAM q value	hsa-miR-137	mmu-miR-137	rno-miR-137
Egr2^†	Early growth response 2	3.73	< 0.001	25.71	25.28	4
Dusp1^†	Dual specificity phosphatase 1	3.26	< 0.001	11.63	12.15	2
Klf4	Kruppel-like factor 4 (gut)	1.77	< 0.001	12.93	15.10	3
Ptgs2^†	Prostaglandin-endoperoxide synthase 2	1.61	< 0.001	7.90	—	—
Dio2	Deiodinase. iodothyronine. type II	1.56	< 0.001	—	8.11	1
Crem	cAMP responsive element modulator	1.51	< 0.001	9.02	10.19	1
Klf2	Kruppel-like factor 2 (lung)	1.42	< 0.001	7.72	10.19	—
Med14	Mediator complex subunit 14	1.41	< 0.001	24.66	24.06	—
Spty2d1	SPT2. Suppressor of Ty. domain containing 1 (S. cerevisiae)	1.38	< 0.001	22.44	19.49	—
Irs2	Insulin receptor substrate 2	1.36	< 0.001	12.93	—	—
Dusp4^†	Dual specificity phosphatase 4	1.35	0.001	28.31	17.14	—
Usp38	Ubiquitin specific peptidase 38	1.31	< 0.001	10.33	—	—
Obfc2a	Oligonucleotide/oligosaccharide-binding fold containing 2A	1.29	< 0.001	22.19	—	—
Sgk1^†	Serum/glucocorticoid regulated kinase 1	1.29	< 0.001	12.93	13.14	3

DIANA = DNA intelligent analysis; SAM = significance analysis of microarrays.
↵* For each gene, the fold change and SAM q value from our previous study of environmental enrichment–induced mRNA expression changes are shown.30
↵† Regulated after miR–137 inhibition in vitro (as shown in Fig. 1B).