Regional differences in grey matter volume between patients with LLD and healthy controls in the pooled meta-analysis
| Maximum | Cluster | ||||
|---|---|---|---|---|---|
| Brain regions* | Talairach coordinates, x, y, z | SDM value | p value | No. of voxels | Breakdown (no. of voxels) |
| LLD < control | |||||
| R lentiform nucleus, putamen | 30, −6, −6 | −1.991 | < 0.001 | 385 | R lentiform nucleus, putamen (144) R claustrum (42) R parahippocampalgyrus, amygdala (80) R lentiform nucleus, globuspallidus (76) R parahippocampalgyrus, hippocampus (19) R parahippocampalgyrus, BA 28,34 (22) R insula (2) |
| L lentiform nucleus, putamen | −26, 8, 0 | −1.310 | 0.002 | 77 | L lentiform nucleus, putamen (61) L claustrum (16) |
| R medial frontal gyrus | 4, 50, −2 | −1.305 | 0.002 | 85 | R medial frontal gyrus, BA 10 (41) R anterior cingulate, BA 10,32 (16) L medial frontal gyrus, BA 10 (19) L anterior cingulate, BA 10,32 (9) |
| R subcallosal gyrus | 4, 18, −12 | −1.265 | 0.002 | 36 | R subcallosal gyrus, BA 25 (16) R anterior cingulate, BA 25,32 (17) R medial frontal gyrus, BA 25 (3) |
| LLD > control | |||||
| R lingual gyrus | 12, −98, −8 | 1.141 | < 0.001 | 217 | R lingual gyrus, BA 17,18 (176) R cuneus, BA 17,18 (30) R inferior occipital gyrus, BA 17 (10) R fusiform gyrus, BA 18 (1) |
BA = Brodmann area; L = left; LLD = late-life depression; R = right; SDM = signed differential mapping.
↵* Regions identified by meta-analysis of coordinates from 11 data sets (voxel-wise p < 0.005 and full-width at half-maximum 20 mm).