Demographic and clinical characteristics of the participants in 9 voxel-based morphometry studies (11 data sets) included in the meta-analysis
| Patients with LLD | Healthy controls | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Study | No. (% female) | Mean age, yr | % Medicated | Illness duration, yr | Severity (scale type), state | Age at onset, yr (EO or LO) | Quality scores (out of 12) | Comorbidity | No. (% female) | Mean age, yr |
| Colloby et al.16 | 38 (71.0) | 74.1 | NA | 23 | 11.6 (GDS) 12.9 (MADRS) depressed or remitted | 51.8 (EO or LO) | 11 | Negative | 30 (66.7) | 74.4 |
| Delaloye et al.27* | 11 (63.6) | 75.82 | 73 | 1.73 | 2.36 (GDS) 11/11 remitted | 74.09 (LO) | 11 | Negative | 30 (73.3) | 70.83 |
| Delaloye et al.27† | 30 (80.0) | 65 | 50 | 29.3 | 2.47 (GDS) 30/30 remitted | 35.67 (EO) | 11 | Negative | 30 (73.3) | 70.83 |
| Egger et al.11 | 14 (71.4) | 71.4 | 71.4 | NA | 21.14 (GDS) 14/14 depressed | > 60 (LO) | 11.5 | Negative | 20 (65) | 72.3 |
| Hwang et al.28 | 70 (0.00) | 79.4 | NA | 8.34 | 29.2 (HDRS) 70/70 depressed | 68.8 (LO) | 10 | Negative | 26 (0.00) | 79.5 |
| Koolschijn et al.15 | 28 (100) | 64.04 | 78.6 | 7.79 | 18.32 (MADRS) 8/28 depressed | 33.04 (EO) | 12 | Negative | 38 (100) | 61.89 |
| Smith et al.12 | 16 (62.5) | 65.3 | 25 | NA | 26 (HDRS) 20.1 (GDS) 16/16 depressed | NA (EO or LO) | 11.5 | Negative | 13 (61.5) | 67.4 |
| Sexton et al.14 | 36 (66.7) | 71.83 | 97.2 | NA | 4.19 (HDRS) 3.83 (GDS) 27/36 remitted | 45.39 (EO or LO) | 10.5 | Some with controlled hypertension and diabetes | 25 (64.0) | 71.76 |
| Xie et al.29‡ | 18 (77.8) | 68.61 | 88.9 | NA | 17.28 (GDS) 18/18 depressed | NA (EO or LO) | 11.5 | Negative | 25 (48.0) | 74.28 |
| Xie et al.29§ | 12 (58.3) | 68.33 | 83.3 | NA | 14.25 (GDS) 12/12 depressed | NA (EO or LO) | 11.5 | MCI | 25 (48.0) | 74.28 |
| Yuan et al.13 | 19 (52.6) | 67.1 | Washout period > 3 mo | 3.7 | 3.1 (HDRS) 19/19 remitted | 64.6 (LO) | 11.5 | Negative | 16 (50) | 67.7 |
EO = early onset; GDS = Geriatric Depression Scale; HDRS = Hamilton Rating Scale for Depression; LLD = late-life depression; LO = late onset; MADRS = Montgomery-Åsberg depression rating scale; MCI = mild cognitive impairment; NA = not available.
↵* Subgroup of patients with early-onset LLD.
↵† Subgroup of patients with late-onset LLD.
↵‡ Subgroup of patients with LLD without amnestic mild cognitive impairment.
↵§ Subgroup of patients with LLD and comorbid amnestic mild cognitive impairment.