Table 4

Associations between white matter tract integrity, symptomatology and neuropsychological performance

	Correlation with tract measurements, r/rho^*

	Left ILF	Left ILF	Forceps	Forceps	Left SLFP	Left SLFT
Variable	FA	AD	major FA	major AD	FA	FA
BPRS Total	−0.34^‡	−0.15	−0.37^‡	−0.32^‡	−0.11	−0.10
BPRS Positive Symptoms^†	−0.21^§	−0.06	−0.33^‡	−0.14	−0.12	−0.18
BPRS Negative Symptoms	−0.39^‡	−0.22^§	−0.38^‡	−0.26^§	−0.16	−0.22^§
HAM-D	−0.43^‡	−0.22	−0.41^‡	−0.28^§	−0.17	−0.08
K10	−0.19	−0.09	−0.18	−0.05	−0.28^§	−0.21^§
DASS Anxiety scale	−0.15	−0.06	−0.18	−0.12	−0.14	−0.14
DASS Stress scale	−0.25^§	−0.11	−0.19^§	−0.11	−0.15	−0.13
RVP-A	0.28^§	0.11	0.26^§	0.14	0.28^§	0.35^‡
RVP-B	0.04	0.07	−0.04	−0.11	0.06	0.08
RAVLT Sum	0.19	0.12	0.18	0.05	0.03	0.11
RAVLT A7	0.16	0.13	0.12	0.04	−0.03	−0.02
COWAT Letters	0.03	−0.03	0.08	−0.12	0.18	0.14
COWAT Animals	0.25^§	0.18	0.23^§	0.10	0.40^‡	0.28^§
SSP	0.03	−0.17	0.09	−0.17	0.15	0.27^§
TMT-A	0.02	0.09	−0.04	0.17	0.04	0.03
TMT-B	0.01	−0.01	0.08	0.09	0.16	0.23^§

AD = axial diffusivity; BPRS = Brief Psychiatric Ratings Scale; COWAT = Controlled Word Association Test; DASS = Depression Anxiety and Stress Scales; FA = fractional anisotropy; HAM-D = Hamilton Rating Scale for Depression; ILF = inferior longitudinal fasciculus; K10 = Kessler-10; RAVLT = Rey Auditory Verbal Learning Test; RVP = Rapid Visual Processing; SSP = spatial span; SLFP = superior longitudinal fasciculus, parietal segment; SLFT = superior longitudinal fasciculus, temporal segment (arcuate); TMT = Trail-Making Test.
↵* Partial correlation examined the association between tract measurements of interest in all participants with clinical scores and z scores of neurocognitive performance controlling for sex and age. Significance was set at p < 0.003, adjusting for multiple comparisons (1-tailed).
↵† Spearman rho correlation analysis examined nonparametric distributions.
↵‡ p < 0.003.
↵§ p < 0.05.