Pearson correlations for variables influencing mGluR2/3 and mGluR5 binding densities in the anterior cingulate cortex within diagnostic groups of the Neuropathology Consortium.
| Diagnosis; variable | Age at death | Fluphenazine equivalent | ||
|---|---|---|---|---|
| All samples, n = 60 | ||||
| mGluR2/3 total | r = −0.410 | p = 0.001 | — | — |
| mGluR2/3 upper | r = −0.464 | p < 0.001 | — | — |
| mGluR2/3 lower | r = −0.273 | p = 0.035 | — | — |
| mGluR5 total | r = 0.087 | p = 0.51 | — | — |
| Controls, n = 15 | ||||
| mGluR2/3 total | r = −0.695 | p = 0.004 | — | — |
| mGluR2/3 upper | r = −0.666 | p = 0.007 | — | — |
| mGluR2/3 lower | r = −0.575 | p = 0.025 | — | — |
| mGluR5 total | r = −0.305 | p = 0.27 | — | — |
| Major depression, n = 15 | ||||
| mGluR2/3 total | r = −0.258 | p = 0.35 | — | — |
| mGluR2/3 upper | r = −0.355 | p = 0.19 | — | — |
| mGluR2/3 lower | r < 0.001 | p = 0.10 | — | — |
| mGluR5 total | r = −0.453 | p = 0.09 | — | — |
| Bipolar disorder, n = 15 | ||||
| mGluR2/3 total | r = −0.045 | p = 0.87 | r = −0.554 | p = 0.032 |
| mGluR2/3 upper | r = −0.286 | p = 0.30 | r = −0.525 | p = 0.045 |
| mGluR2/3 lower | r = 0.170 | p = 0.55 | r = −0.482 | p = 0.07 |
| mGluR5 total | r = 0.023 | p = 0.93 | r = −0.131 | p = 0.64 |
| Schizophrenia, n = 15 | ||||
| mGluR2/3 total | r = −0.528 | p = 0.043 | r = −0.109 | p = 0.70 |
| mGluR2/3 upper | r = −0.458 | p = 0.09 | r = 0.016 | p = 0.96 |
| mGluR2/3 lower | r = −0.515 | p = 0.049 | r = −0.225 | p = 0.42 |
| mGluR5 total | r = 0.505 | p = 0.06 | r = 0.477 | p = 0.07 |