Demographic and clinical characteristics of the sample (n = 2679)
| Characteristic | No. (%)* |
|---|---|
| Age, mean ± SD, yr | 50.33 ± 14.91 |
| Sex | |
| Male | 811 (30.3) |
| Female | 1868 (69.7) |
| Education† | |
| Elementary education | 554 (20.7) |
| Junior school | 1237 (46.3) |
| High school | 541 (20.2) |
| University degree | 342 (12.8) |
| Marital status† | |
| Single, never married | 450 (16.8) |
| Married | 1852 (69.2) |
| Divorced/separated | 167 (6.2) |
| Widowed | 208 (7.8) |
| Major depression over follow-up | |
| Without major depression | 1875 (70.0) |
| With major depression | 804 (30.0) |
| Childhood maltreatment | |
| Emotional maltreatment | 406 (15.2) |
| Physical maltreatment | 258 (9.6) |
| Sexual abuse | 75 (2.8) |
| Variability in SERT gene 5-HTTLPR L/S biallelic polymorphism | |
| L allele | 2746 (51.3) |
| S allele | 2612 (48.7) |
| L/L | 713 (26.6) |
| L/S | 1320 (49.3) |
| S/S | 646 (24.1) |
| 5-HTTLPR triallelic polymorphism (rs25531) | |
| l allele | 2526 (47.1) |
| s allele | 2832 (52.9) |
| l/l | 624 (23.3) |
| l/s | 1278 (47.7) |
| s/s | 777 (29.0) |
| Variability at BDNF gene Val66Met polymorphism† | |
| Val (C) allele | 4032 (78.0) |
| Met (T) allele | 1134 (22.0) |
| Val/Val (CC) | 1574 (60.9) |
| Val/Met (CT) | 884 (34.2) |
| Met/Met (TT) | 125 (4.9) |