Age, mean ± SD, yr | 50.33 ± 14.91 |
Sex | |
Male | 811 (30.3) |
Female | 1868 (69.7) |
Education† | |
Elementary education | 554 (20.7) |
Junior school | 1237 (46.3) |
High school | 541 (20.2) |
University degree | 342 (12.8) |
Marital status† | |
Single, never married | 450 (16.8) |
Married | 1852 (69.2) |
Divorced/separated | 167 (6.2) |
Widowed | 208 (7.8) |
Major depression over follow-up | |
Without major depression | 1875 (70.0) |
With major depression | 804 (30.0) |
Childhood maltreatment | |
Emotional maltreatment | 406 (15.2) |
Physical maltreatment | 258 (9.6) |
Sexual abuse | 75 (2.8) |
Variability in SERT gene 5-HTTLPR L/S biallelic polymorphism | |
L allele | 2746 (51.3) |
S allele | 2612 (48.7) |
L/L | 713 (26.6) |
L/S | 1320 (49.3) |
S/S | 646 (24.1) |
5-HTTLPR triallelic polymorphism (rs25531) | |
l allele | 2526 (47.1) |
s allele | 2832 (52.9) |
l/l | 624 (23.3) |
l/s | 1278 (47.7) |
s/s | 777 (29.0) |
Variability at BDNF gene Val66Met polymorphism† | |
Val (C) allele | 4032 (78.0) |
Met (T) allele | 1134 (22.0) |
Val/Val (CC) | 1574 (60.9) |
Val/Met (CT) | 884 (34.2) |
Met/Met (TT) | 125 (4.9) |