Estimates of mixed linear models adjusted for age, sex and JNK3 CSF level and their associations with baseline or follow-up MMSE scores of patients with Alzheimer disease
| CSF JNK3 | Estimate (SE) | p value |
|---|---|---|
| MMSE score at baseline | ||
| Intercept | 21.8 (2.0) | < 0.001 |
| Age, yr | 0.09 (0.11) | 0.41 |
| Sex, men v. women | −0.83 (2.32) | 0.72 |
| JNK3 tertiles | ||
| 73.1 ODU | Ref. | |
| 73.2–89 ODU | −1.41 (2.65) | 0.60 |
| > 89 ODU | −0.66 (0.81) | 0.81 |
| Change in MMSE over the follow-up | ||
| Time, yr | −1.80 (0.83) | 0.028 |
| Age × time | 0.05 (0.05) | 0.31 |
| Sex × time | −0.59 (1.09) | 0.59 |
| JNK3 tertiles × time | ||
| 73.1 ODU | Ref. | |
| 73.2–89 ODU | −0.11 (1.04) | 0.92 |
| > 89 ODU | 2.44 (1.18) | 0.041 |
Aβ = amyloid-β; CSF = cerebrospinal fluid; MMSE = Mini–Mental State Examination; ODU = optical density units; SE = standard error.