Table 2

Crude and adjusted main effects on DSM-IV major depression

		Unadjusted		Adjusted for age, sex and baseline MD

Variable	No.	OR (95% CI)	p value	OR (95% CI)	p value
Genes
SERT 5-HTTLPR L/S biallelic (S/* v. L/L)	2679	1.054 (0.871–1.276)	0.59	1.015 (0.828–1.244)	0.89
5-HTTLPR triallelic (s/* v. l/l)	2679	1.021 (0.836–1.247)	0.84	1.005 (0.813–1.244)	0.96
BDNF Val66Met polymorphism^† (Met/* v. Val/Val)	2583	0.797 (0.667–0.952)	0.012	0.797 (0.659–0.963)	0.019
Type of maltreatment^†
Emotional	2674	2.683 (2.156–3.345)	< 0.001	2.096 (1.659–2.650)	< 0.001
Physical	2676	3.128 (2.394–4.087)	< 0.001	2.502 (1.881–3.326)	< 0.001
Sexual abuse	2676	2.561 (1.601–4.097)	< 0.001	1.801 (1.099–2.952)	< 0.001
Any abuse	2676	2.569 (2.096–3.148)	< 0.001	2.013 (1.621–2.500)	< 0.001