Table 4

Pairwise comparisons of the regions with a significant effect of group on volume*

CUD v. controlNCUD v. controlCUD v. NCUD
Brain regionβ†SEβp valued‡β†SEβp valued‡β†SEβp valued‡
Amygdala§−276.0034.50< 0.0011.24−355.5545.50< 0.0011.73−79.6045.460.08
Putamen§−505.79117.45< 0.0010.70−926.14154.97< 0.0011.33−420.36154.830.0070.52
Insula−427.10107.9< 0.0010.57−197.00142.400.17230.13142.270.11
Parahippocampal gyrus−241.7148.25< 0.0010.76−409.4063.66< 0.0011.23−167.6963.600.009
Fusiform gyrus−1024.10195.80< 0.0010.80−1238.32258.38< 0.0010.87−214.19258.140.41

  • CUD = cannabis use disorder; NCUD = no cannabis use disorder; SEβ = standard error of β.

  • ↵* All results are adjusted for age, slice thickness and intracranial volume. Significant from p < 0.01.

  • ↵† Adjusted mean difference between the 2 groups.

  • ↵‡ Calculated only for significant regions of interest.

  • ↵§ Based on the FreeSurfer segmentation output.

  • ↵ Based on the FreeSurfer Desikan-Killiany Atlas.