Interactions between 5-HTTLPR triallelic, BDNF Val66Met and childhood maltreatment on adult major depression (adjusted for sex, age and baseline MD)
| Type of childhood maltreatment, OR (95% CI), z score, p value | ||||
|---|---|---|---|---|
| Interaction | Emotional | Physical | Sexual | Any |
| Gene × environment | ||||
| Maltreatment × 5-HTTLPR | 1.445 (0.838–2.491), z = 1.32, p = 0.19 | 2.744 (1.387–5.428), z = 2.90, p = 0.004 | 5.611 (1.511–20.838), z = 2.58, p = 0.010 | 2.017 (1.217–3.341), z = 2.72, p = 0.006 |
| Maltreatment × BDNF | 1.576 (0.960–2.586), z = 1.80, p = 0.07 | 0.842 (0.457–1.550), z = –0.55, p = 0.58 | 1.080 (0.386–3.018), z = 0.15, p = 0.88 | 1.418 (0.898–2.239), z = 1.50, p = 0.13 |
| Gene × gene × environment | ||||
| Maltreatment × 5-HTTLPR × BDNF | 1.733 (1.033–2.909), z = 2.08, p = 0.037 | 1.187 (0.625–2.254), z = 0.53, p = 0.60 | 2.249 (1.088–4.647), z = 2.19, p = 0.029 | 1.783 (1.106–2.875), z = 2.37, p = 0.018 |
CI = confidence interval; MD = major depression; OR = odds ratio.