Receiver operating characteristics curve evaluation for the different cerebrospinal fluid biomarkers in controls with neurologic disease and patients with Alzheimer disease
| CSF biomarkers | AUC (SE) | Threshold value | Sensitivity, % | Specificity, % | Youden Index |
|---|---|---|---|---|---|
| Aβ42, pg/mL | 0.89 (0.05) | 585 | 0.83 | 0.92 | 1.76 |
| T-τ, pg/mL | 0.91 (0.04) | 345 | 0.83 | 0.96 | 1.79 |
| p181τ, pg/mL | 0.91 (0.04) | 73 | 0.80 | 0.92 | 1.72 |
| JNK3, ODU | 0.75 (0.07) | 70.3 | 0.80 | 0.73 | 1.56 |
Aβ = amyloid-β; AUC = area under the curve; CSF = cerebrospinal fluid; ODU = optical density units; p181τ = τ phosphorylated at threonine 181; SE = standard error; T-τ = total τ.