Table 3

Differential activation between groups in response to matching emotional faces and the control shape condition (all faces v. shapes)

All faces v. shapesCluster sizeMNI spacet*
SAD > HC———
SAD < HC†———
 Left medial prefrontal cortex361−8, 18, 563.96
 Left lateral prefrontal cortex989−42, 24, 244.23
 Right fusiform gyrus64930, −74, −163.54
 Left fusiform gyrus245−28, −74, −103.59
 Left precuneus1611−4, −68, 423.81
 Right lateral temporal cortex17268, −28, −104.28
 Left lateral temporal cortex362−62, −44, −143.79
 Cerebellum76412, −56, −464.20
HC > WBS
 Right primary visual cortex44918, −98, 63.70
 Left primary visual cortex159−16, −98, −23.16
 Right lateral occipital area37542, −62, 83.85
HC < WBS‡
 Right medial temporal gyrus temporal operculum13064, −18, −163.45
 Right supplementary motor area42512, −18, 683.16
SAD > WBS
 Right lateral occipital area35148, −68, 24.04
SAD < WBS†
 Medial prefrontal cortex/ACC430−4, 50, 163.29
 Left dorsal prefrontal cortex602−24, 30, 404.07
 Left superior temporal gyrus185−52, −42, −143.95
 Right lateral temporal cortex38164, −20, −184.34
 Left lateral temporal cortex177−58, −46, −123.84

  • ACC = anterior cingulate cortex; HC = healthy controls; MNI = Montreal Neurological Institute; SAD = social anxiety disorder; WBS = Wlliams–Beuren syndrome.

  • ↵* Statistics correspond to a corrected threshold pFWE < 0.05 estimated using Monte Carlo simulations.

  • ↵† More activation in controls, more deactivation in SAD.

  • ↵‡ More deactivation in controls.