Table 1

Twenty-two single nucleotide polymorphisms included in the genetic association study

Gene	SNP	Chr. position	Gene position	Major/minor alleles	Minor allele frequency	References^*
LBP	rs2232571	20:36974084	5′ upstream	T/C	0.134	62
CD14	rs5744455	5:140013307	5′ upstream	C/T	0.208	63
	rs5744441	5:140016847	5′ upstream	C/T	0.213	64
TLR4	rs4986790	9:120475302	Nonsynonymous	A/G	0.056	61
	rs4986791	9:120475602	Nonsynonymous	C/T	0.053	61
	rs11536889	9:120478131	3′UTR	G/C	0.144	65
MyD88	rs4988453	3:38179254	5′ upstream	C/A	0.042	66
	rs4988457	3:38182136	Noncodifying exon	C/G	0.043	66
	rs7744	3:38184021	3′UTR	A/G	0.153	50
IRAK4	rs4251545	12:44180295	Nonsynonymous	G/A	0.110	67
IRAK1	rs3027898	X:153275890	3′ downstream	A/C	0.199	68
NFKB1	rs28362491	4:103422155	5′ upstream	ATTG/-	0.332	69
	rs72696119	4:103422504	5′UTR	C/G	0.329	70
	rs2272676	4:103423326	Splicing region	G/T	0.274	NR
	rs230529	4:103457418	Intron region	G/A	0.329	71
	rs4699030	4:103503824	Intron region	G/C	0.338	71
	rs148268461	4:103534740	Splicing region	-/A	0.053	NR
IL6	rs1800796	7:22766246	5′ upstream	G/C	0.069	72
	rs1800795	7:22766645	5′ upstream	G/C	0.350	58
IL1B	rs1143634	2:113590390	Synonymous	C/T	0.227	58
	rs1143627	2:113594387	5′UTR	T/C	0.378	73
	rs16944	2:113594867	5′ upstream	G/A	0.375	58

NR = no reference; SNP = single nucleotide polymorphism; UTR = untranslated region.
↵* Includes 1 relevant reference on which the polymorphism selection was based. In cases of NR, the polymorphism was selected based just on its gene position. These references can be found in Appendix 1, available at jpn.ca.