Table 1

Top 40 M5 module genes ranked by module membership. Differential gene expression between wild-type and Rasgrf2^−/− mice and module membership statistics, as well as human orthologues, are also included.

Rank	Mouse gene symbol	Differential expression			Module membership			Human gene symbol

		logFC	t	p value	MM	p value	kWithin
1	Glrx1	3	38.27	< 0.001	0.99	< 0.001	76.61	—
2	LOC666403	4.48	59.71	< 0.001	0.99	< 0.001	76.23	—
3	1200015F23Rik	2.15	42.63	< 0.001	0.99	< 0.001	75.97	—
4	Tmem87a	−2.38	−42.17	< 0.001	−0.99	< 0.001	75.47	TMEM87A
5	Lrrc57	2.44	34.6	< 0.001	0.99	< 0.001	75.23	LRRC57
6	Ccndbp1	1.43	24.13	< 0.001	0.99	< 0.001	73.6	CCNDBP1
7	9930021D14Rik	1.31	22.86	< 0.001	0.99	< 0.001	72.98	—
8	Slc25a18	2.25	23.78	< 0.001	0.98	< 0.001	72.8	SLC25A18
9	2810410P22Rik	1.84	19.75	< 0.001	0.98	< 0.001	71.23	—
10	Pla2g4b	0.43	11.35	< 0.001	0.98	< 0.001	70.12	PLA2G4B
11	Gfer	0.66	14.77	< 0.001	0.98	< 0.001	68.74	GFER
12	Cops8	−2.91	−21.1	< 0.001	−0.98	< 0.001	67.93	COPS8
13	Adamts9	0.85	15.38	< 0.001	0.98	< 0.001	67.84	ADAMTS9
14	Eme2	−1.74	−20.75	< 0.001	−0.98	< 0.001	68	EME2
15	C920004C08Rik	−0.98	−16.06	< 0.001	−0.98	< 0.001	66.72	—
16	Slc39a9	0.65	12.83	< 0.001	0.97	< 0.001	66.17	SLC39A9
17	Arrdc3	2.07	16.82	< 0.001	0.97	< 0.001	68.47	ARRDC3
18	2810423A18Rik	1.51	17.65	< 0.001	0.97	< 0.001	68.02	—
19	Mad	1.21	17.31	< 0.001	0.97	< 0.001	68.05	—
20	A330021E22Rik	1.28	16.43	< 0.001	0.97	< 0.001	64.42	C7orf63
21	Arl5a	1.7	16.24	< 0.001	0.97	< 0.001	66.31	ARL5A
22	LOC229810	−1.64	−18.56	< 0.001	−0.97	< 0.001	68.29	—
23	Zap3-pending	0.58	13.07	< 0.001	0.97	< 0.001	65.62	—
24	Clstn1	−1.51	−18.54	< 0.001	−0.97	< 0.001	66.34	CLSTN1
26	Vrk1	0.85	−13.51	< 0.001	0.96	< 0.001	62.83	VRK1
27	2310002B06Rik	−0.6	−12.66	< 0.001	−0.96	< 0.001	61.92	—
28	Polr3f	−0.38	−9.54	< 0.001	−0.96	< 0.001	61.86	POLR3F
29	Gpr19	0.81	11.99	< 0.001	0.96	< 0.001	62.33	GPR19
30	Mid1	1.61	17.27	< 0.001	0.96	< 0.001	62.82	MID1
31	A630064P09Rik	−0.46	−10.17	< 0.001	−0.96	< 0.001	59.67	—
32	Ccl27	−1.79	−15.52	< 0.001	−0.96	< 0.001	60.68	—
33	8430432M10Rik	0.67	11.92	< 0.001	0.95	< 0.001	59.82	—
34	Ndufb10	1.09	15.91	< 0.001	0.95	< 0.001	59.86	NDUFB10
35	Ube2i	−1.04	−12.22	< 0.001	−0.95	< 0.001	56.05	UBE2I
36	Tubgcp4	0.62	10.28	< 0.001	0.95	< 0.001	55.84	TUBGCP4
37	Bub1b	0.36	8.56	< 0.001	0.94	< 0.001	53.49	BUB1B
38	Ehd4	0.67	9.79	< 0.001	0.94	< 0.001	54.66	EHD4
39	Rps2	−0.51	−10.47	< 0.001	−0.94	< 0.001	53.67	RPS2
40	Arhgap12	1.12	11.84	< 0.001	0.94	< 0.001	53.33	ARHGAP12

logFC = fold change on log2 scale between wild-type and Rasgrf2^−/−; MM = module membership; kWithin = number of connections between a gene and other genes in a module.