Table 1
Changes in motor behaviour, anxiety- and depression-related behaviour, and addiction-related behaviour in constitutive VMAT2-HET mice*
| VMAT2 | VMAT2DBHcre | VMAT2SERTcre | VMAT2DATcre | ||
|---|---|---|---|---|---|
| Behaviour type | Change observed | NE, 5-HT, DA | NE | 5-HT | DA |
| Motor behaviour | Spontaneous locomotion (horizontal activity) |
 | ∅ | ∅ |
 |
| Rotarod (latency to fall) | ∅ | ∅ | ∅ | ∅ | |
| Anxiety | Elevated plus maze (time in open arm) | ∅ | ∅ | ∅ | ∅ |
| Novelty suppressed feeding (feeding latency) | ∅ | ∅ | ∅ | ∅ | |
| Depression | Forced swim test (immobility %) | ∅ | ∅ | ∅ | ∅ |
| Sucrose preference test (% of preference) |
 | ∅ | ∅ | ∅ | |
| Addiction | Acute motor response to cocaine |
 | ∅ |
 | ∅ |
| Acute motor response to amphetamine |
 | ∅ | ∅ |
 | |
| Cocaine sensitization |
 | ∅ |
 | ∅ | |
| Amphetamine-conditioned place preference |
 | ∅ | ∅ | ∅ | |
∅ = no change;
= significant decrease;
= significant increase; 5-HT = serotonin; DA = dopamine; HET = heterozygous; NE = norepinephrine; VMAT = vesicular monoaminergic transporter-2.
↵* The 3 monoaminergic systems are affected compared with the conditional VMAT2DBHcre-HET, VMAT2SERTcre-HET and VMAT2DATcre-HET mouse lines (in which only 1 specific monoaminergic system is altered.
