Table 2

Summary of mouse genes in the M5 module with high module membership and gene significance (correlated with Rasgrf2 expression levels) and their corresponding genetic association with binge drinking in humans.

	Mouse gene expression					Human genetic association

	Wild-type v. Rasgrf2^−/−			Rasgrf2 expression		Binge drinking

Mouse gene	MM	FC	p value	r	p value	Human gene	n	SNP^*	p value
Ehd4	0.94	0.67	< 0.001	0.71	< 0.001	EHD4	30	rs1648821	< 0.001
Klc1	0.77	0.78	< 0.001	0.64	0.004	KLC1	10	rs861550	0.009
Slc5a5	0.74	1.23	< 0.001	0.66	0.003	SLC5A5	6	rs7508025	0.011
Capn3	0.66	0.17	0.006	0.67	0.002	CAPN3	9	rs4924675	0.017
Dcp1b	0.83	0.58	< 0.001	0.61	0.008	DCP1B	16	rs972657	0.022
Snapc3	0.82	0.38	< 0.001	0.62	0.006	SNAPC3	10	rs6474915	0.023
Emp2	0.79	0.44	< 0.001	0.59	0.009	EMP2	30	rs6498070	0.024
Lypd6b	0.79	0.39	< 0.001	0.60	0.008	LYPD6B	49	rs10490383	0.026
Ccl17	0.63	0.35	0.004	0.60	0.008	CCL17	8	rs4784805	0.026
Snapc1	0.81	0.42	< 0.001	0.63	0.005	SNAPC1	8	rs7143626	0.036
Adamts9	0.98	0.85	< 0.001	0.61	0.007	ADAMTS9	67	rs6793277	0.037
Gpr176	0.73	0.32	< 0.001	0.63	0.005	GPR176	26	rs17646847	0.045
Map4k5	0.83	0.23	< 0.001	0.64	0.004	MAP4K5	20	rs12881869	0.049
Neo1	0.93	0.61	< 0.001	0.63	0.005	NEO1	30	rs4132535	0.06
Pgpep1	0.85	0.45	< 0.001	0.61	0.008	PGPEP1	11	rs1978423	0.09
Pbx4	0.67	0.24	0.003	0.65	0.003	PBX4	7	rs12610185	0.11
Rnd3	0.92	0.89	< 0.001	0.63	0.005	RND3	12	rs1528429	0.12
Zfp609	0.73	0.14	0.005	0.61	0.008	ZNF609	10	rs547818	0.12
Polr3k	0.81	0.28	< 0.001	0.76	< 0.001	POLR3K	5	rs216600	0.13
A330021E22Rik	0.97	1.28	< 0.001	0.60	0.008	C7orf63	15	rs11563435	0.17
Tmco5	0.75	0.18	0.002	0.69	0.002	TMCO5A	5	rs1604528	0.19
2410076I21Rik	0.79	0.26	< 0.001	0.62	0.006	C15orf60	13	rs7176074	0.24
Lrrc57	0.99	2.44	< 0.001	0.61	0.007	LRRC57	1	rs10851410	0.50
Tubgcp4	0.95	0.62	< 0.001	0.70	0.001	TUBGCP4	3	rs2412780	0.53
Itgb3bp	0.88	0.61	< 0.001	0.74	< 0.001	ITGB3BP	9	rs3790867	0.54
Dguok	0.83	0.38	< 0.001	0.62	0.006	DGUOK	9	rs13411881	0.56
Xkr8	0.72	0.35	< 0.001	0.63	0.005	XKR8	6	rs4908382	0.74
Arl5a	0.97	1.70	< 0.001	0.64	0.004	ARL5A	2	rs10182533	0.78

FC = fold change on log2 scale between wild-type and Rasgrf2^−/− mice; MM = module membership; SNP = single-nucleotide polymorphism.
↵* SNP with the lowest p value (best SNP) for the gene.