Medication | Subgroup (no. of patients)† | Brightness induction‡ | Contrast suppression‡ | ||||
---|---|---|---|---|---|---|---|
Mood stabilizer (14) | Antipsychotic (21) | Antidepressant (78) | β | p value | β | p value | |
Valproate | 0.29 | 0.10 | 0.03 | 0.060 | 0.58 | −0.369 | 0.001§ |
Lamotrigine | 0.43 | 0.14 | 0.05 | 0.136 | 0.18 | −0.072 | 0.45 |
Pregabalin | 0.29 | — | 0.05 | 0.054 | 0.63 | −0.076 | 0.47 |
Benzodiazepine | 0.07 | 0.05 | 0.05 | 0.040 | 0.71 | 0.060 | 0.55 |
SSRI, SARI or SMS | 0.36 | 0.43 | 0.68 | −0.103 | 0.35 | −0.092 | 0.37 |
SNRI or tricyclic antidepressant | 0.36 | 0.14 | 0.32 | −0.001 | 0.99 | −0.036 | 0.75 |
Tetracyclic antidepressant | 0.07 | — | 0.10 | −0.039 | 0.70 | −0.036 | 0.71 |
NDRI | — | 0.05 | 0.06 | −0.032 | 0.75 | −0.027 | 0.78 |
Agomelatine | — | — | 0.01 | −0.042 | 0.68 | −0.029 | 0.77 |
Other | 0.07 | 0.05 | 0.03 | 0.023 | 0.82 | 0.116 | 0.24 |
NDRI = norepinephrine–dopamine reuptake inhibitor; SARI = serotonin antagonist and reuptake inhibitor; SMS = serotonin modulator and stimulator (vortioxetine); SNRI = serotonin-norepinephrine reuptake inhibitor; SSRI = selective serotonin reuptake inhibitor.
↵* Nineteen patients used no medication. Some patients used multiple medications.
↵† Proportion of patients using the medication in each subgroup.
↵‡ Brightness induction and contrast suppression β coefficients and p values are from linear regression analysis.
↵§ p < 0.01.