Demographic and clinical characteristics of study participants
| Group: mean ± SD (range)* | ||
|---|---|---|
| Charcteristic | Prader Willi (n = 24) | Control (n = 29) |
| Age, yr | 26.3 ± 6.9 (18–39) | 28.2 ± 7.7 (19–45) |
| Body mass index | 30.2 ± 6.4 (21.5–43.4) | 22.2 ± 2.0 (17.7–25.0) |
| IQ† | ||
| Total score | 68.3 ± 12.1 (40–92) | 110.8 ± 11.4 (90–131) |
| Verbal | 75.3 ± 13.3 (40–99) | 111.2 ± 12.5 (89–133) |
| Performance | 72.5 ± 13.6 (44–102) | 112.4 ± 8.5 (93–127) |
| Genetic diagnosis, no. | ||
| Type I deletion | 5 | — |
| Type II deletion | 10 | — |
| Uniparental disomy | 6 | — |
| Imprinting defect | 3 | — |
| Metabolic syndrome | ||
| Type 2 diabetes mellitus | 3 | — |
| Dyslipidemia | 6 | — |
| Arterial hypertension | 0 | — |
| Obsessive–compulsive behaviour | ||
| Compulsive | — | — |
| Behaviour Checklist score‡ | ||
| Ordering (range 0–7) | 1.5 ± 2.0 (0–7) | 0.1 ± 0.4 (0–1) |
| Completeness/incompleteness (range 0–7) | 0.6 ± 1.0 (0–4) | 0.1 ± 0.3 (0–1) |
| Cleaning/tidiness (range 0–7) | 0.6 ± 1.0 (0–4) | 0.03 ± 0.2 (0–1) |
| Checking/touching (range 0–5) | 0.2 ± 0.4 (0–1) | 0.1 ± 0.4 (0–2) |
| Deviant grooming/self picking (range 0–4) | 1.0 ± 0.9 (0–2) | — |
| Y-BOCS obsessions (range 0–20) | 1.9 ± 4.5 (0–16) | 0.2 ± 0.6 (0–3) |
| Y-BOCS compulsions (range 0–20) | 7.0 ± 6.5 (0–16) | 0.2 ± 0.5 (0–2) |
| Hyperphagia Questionnaire | — | — |
| Total score (range 0–44) | 18.8 ± 10.1 (0–38) | — |
| Behaviour (range 0–20) | 9.1 ± 5.8 (0–20) | — |
| Drive (range 0–16) | 7.2 ± 4.2 (0–14) | — |
| Severity (range 0–8) | 2.5 ± 2.6 (0–8) | — |