Comparison of callosal regional areas between patients with bipolar disorder I and healthy controls*
| BD, n = 172 | Control, n = 146 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Region | No.† | Area, mm2; raw mean ± SD | Area, log scale; raw mean ± SD | No.† | Area, mm2; raw mean ± SD | Area, log scale; raw mean ± SD) | Estimated adjusted group difference; log scale (95% CI) | Statistic | p value‡ | Partial η2 for diagnosis | Significant cofactors/ covariates (partial η2) |
| Rostrum | 169 | 25.67 ± 8.89 | 3.19 ± 0.34 | 146 | 24.48 ± 8.99 | 3.13 ± 0.36 | 0.044 (−0.067 to 0.155) | F1,301 = 0.607 | 0.67 | 0.002 | Age (0.065) TBV (0.032) |
| Genu | 170 | 132.72 ± 27.94 | 4.87 ± 0.21 | 142 | 138.29 ± 22.0 | 4.92 ± 0.16 | −0.049 (−0.109 to 0.010) | F1,298 = 2.643 | 0.28 | 0.009 | TBV (0.124) |
| Rostral body | 168 | 92.78 ± 16.20 | 4.51 ± 0.17 | 141 | 93.29 ± 14.06 | 4.52 ± 0.15 | 0.003 (−0.048 to 0.054) | F1,295 = 0.013 | 0.91 | < 0.001 | TBV (0.090) |
| Anterior midbody | 170 | 70.31 ± 12.40 | 4.24 ± 0.17 | 143 | 73.59 ± 10.04 | 4.29 ± 0.14 | −0.050 (−0.099 to −0.001) | F1,299 = 4.007 | 0.17 | 0.013 | TBV (0.116) |
| Posterior midbody | 168 | 59.90 ± 10.90 | 4.08 ± 0.18 | 144 | 63.92 ± 9.43 | 4.15 ± 0.15 | −0.082 (−0.133 to −0.030) | F1,298 = 9.771 | 0.019 | 0.032 | Site (0.038) TBV (0.087) |
| Isthmus | 171 | 50.89 ± 12.64 | 3.90 ± 0.25 | 145 | 57.07 ± 11.91 | 4.02 ± 0.21 | −0.119 (−0.191 to −0.047) | F1,302 = 10.496 | 0.019 | 0.034 | TBV (0.093) |
| Splenium | 168 | 180.07 ± 28.66 | 5.18 ± 0.16 | 144 | 190.28 ± 24.55 | 5.24 ± 0.13 | −0.071 (−0.117 to −0.024) | F1,298 = 9.057 | 0.019 | 0.029 | TBV (0.114) |
BD = bipolar disorder; CI = confidence interval; SD = standard deviation; TBV = total brain volume.
↵* Analyses were controlled for age, sex, handedness, site, past alcohol abuse or dependence, lithium and antipsychotic medication status (yes v. no), symptomatic status (yes v. no) and TBV and were conducted after exclusion of outliers.
↵† Without outliers.
↵‡ False-discovery rate–corrected.