Comparison of callosal regional areas between patients with a positive history of psychotic features and patients without such a history*
| BD with psychotic features, n = 113 | BD without psychotic features, n = 58 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Region | No.† | Area, mm2; raw mean ± SD | Area, log scale; raw mean ± SD | No.† | Area, mm2; raw mean ± SD | Area, log scale; raw mean ± SD) | Estimated adjusted group difference; log scale (95% CI) | Statistic | p value‡ | Partial η2 for diagnosis | Significant cofactors/ covariates (partial η2) |
| Rostrum | 112 | 26.84 ± 9.61 | 3.23 ± 0.36 | 56 | 23.40 ± 6.90 | 3.11 ± 0.29 | 0.167 (0.043 to 0.292) | F1,153 = 7.025 | 0.043 | 0.044 | Site (0.068) Age (0.079) TBV (0.036) |
| Genu | 113 | 133.55 ± 29.33 | 4.87 ± 0.22 | 56 | 131.16 ± 25.36 | 4.86 ± 0.20 | −0.031 (−0.107 to 0.046) | F1,154 = 0.631 | 0.67 | 0.004 | TBV (0.171) |
| Rostral body | 110 | 92.79 ± 16.24 | 4.52 ± 0.17 | 57 | 92.58 ± 16.34 | 4.51 ± 0.17 | 0.020 (−0.043 to 0.084) | F1,152 = 0.394 | 0.67 | 0.003 | Site (0.063) TBV (0.050) |
| Anterior midbody | 112 | 71.12 ± 12.20 | 4.25 ± 0.17 | 56 | 69.29 ± 12.48 | 4.22 ± 0.18 | 0.026 (−0.037 to 0.089) | F1,153 = 0.672 | 0.67 | 0.004 | TBV (0.129) |
| Posterior midbody | 112 | 60.28 ± 11.13 | 4.08 ± 0.18 | 57 | 58.25 ± 11.29 | 4.05 ± 0.19 | 0.023 (−0.044 to 0.090) | F1,154 = 0.447 | 0.67 | 0.003 | TBV (0.122) |
| Isthmus | 112 | 50.99 ± 12.50 | 3.90 ± 0.24 | 56 | 51.26 ± 12.37 | 3.91 ± 0.24 | −0.029 (−0.116 to 0.057) | F1,153 = 0.445 | 0.67 | 0.003 | TBV (0.132) |
| Splenium | 110 | 180.85 ± 28.50 | 5.18 ± 0.16 | 57 | 178.16 ± 29.22 | 5.17 ± 0.16 | −0.018 (−0.105 to 0.070) | F1,152 = 0.159 | 0.77 | 0.001 | TBV (0.125) |
BD = bipolar disorder; CI = confidence interval; SD = standard deviation; TBV = total brain volume.
↵* Analyses were controlled for age, sex, handedness, site, past alcohol abuse or dependence, lithium and antipsychotic medication status (yes v. no), symptomatic status (yes v. no), duration of illness and TBV and were conducted after exclusion of outliers. Data about psychotic features missing for 1 patient with bipolar disorder.
↵† Without outliers.
↵‡ False-discovery rate–corrected.