c.709–1G > A GRN mutation carriers | |||
---|---|---|---|
Characteristic | Control (n = 10) | Asymptomatic (n = 12) | FTLD (n = 7) |
Age range, yr | 31–69 | 34–72 | 54–70 |
Mean age, yr | 51.8 ± 4.3 | 56.8 ± 3.2 | 65.3 ± 2.3 |
Sex, female:male | 5:5 | 6:6 | 7:0 |
Age at onset, yr | — | — | 60.7 ± 1.7 |
Phenotype | Asymptomatic | Asymptomatic | FTD-bv; CBS |
Serum PGRN levels (ng/mL) | 126.7 ± 13 | 47.5 ± 7.3 | 44 ± 5.6 |
CBS = corticobasal syndrome; FTD-bv = frontotemporal dementia (behaviour); PGRN = progranulin.