Cravers (n = 9); mean ± SEM | Noncravers (n = 3); mean ± SEM | |||||||
---|---|---|---|---|---|---|---|---|
ROI | Neutral cues | Cocaine cues | %ΔBPND | p value* | Neutral cues | Cocaine cues | %ΔBPND | p value* |
mOFC | 0.538 ± 0.077 | 0.430 ± 0.067 | −20.1 | 0.010† | 0.663 ± 0.173 | 0.810 ± 0.231 | 22.1 | 0.038 |
latOFC | 0.626 ± 0.080 | 0.593 ± 0.075 | −5.8 | 0.18 | 0.696 ± 0.134 | 0.776 ± 0.163 | 11.4 | 0.07 |
mPFC | 0.462 ± 0.061 | 0.414 ± 0.052 | −10.4 | 0.14 | 0.656 ± 0.191 | 0.663 ± 0.151 | 1.1 | 0.90 |
DLPFC | 0.456 ± 0.062 | 0.411 ± 0.055 | −9.9 | 0.11 | 0.593 ± 0.137 | 0.646 ± 0.143 | 8.9 | 0.27 |
ACC | 0.562 ± 0.057 | 0.500 ± 0.045 | −11.0 | 0.040 | 0.716 ± 0.168 | 0.800 ± 0.182 | 11.7 | 0.07 |
VTA | 1.700 ± 0.150 | 1.581 ± 0.133 | −7.0 | 0.12 | 1.686 ± 0.504 | 1.90 ± 0.431 | 12.6 | 0.11 |
SN/VTA | 2.128 ± 0.178 | 1.993 ± 0.118 | −6.3 | 0.23 | 2.136 ± 0.294 | 2.330 ± 0.086 | 9.1 | 0.45 |
ACC = anterior cingulate cortex; BPND = binding potential; DLPFC = dorsolateral prefrontal cortex; lat = lateral; m = medial; OFC = orbitofrontal cortex; PFC = prefrontal cortex; ROI = region of interest; SEM = standard error of the mean; SN = substantia nigra; VTA = ventral tegmental area.
↵* All p values derived from post hoc comparisons, except those for the VTA and SN/VTA, which were derived from paired-samples t tests.
↵† p < 0.05 following Bonferroni correction.