Clusters showing grey-matter differences between patients with bipolar disorder and controls*
| Cluster peak/regions | Peak MNI coordinates, x, y, z | SDM Z value | p value | Voxel size | Brodmann area | Cluster breakdown |
|---|---|---|---|---|---|---|
| BD v. controls | ||||||
| BD > controls | ||||||
| None | — | — | — | — | — | — |
| BD < controls | ||||||
| Superior frontal gyrus, medial part | −2, 54, 12 | −2.704 | < 0.001 | 4369 | 9, 10, 23, 32 | Bilateral superior frontal gyrus, medial part, left anterior cingulate/paracingulate gyri, bilateral median cingulate/paracingulate gyri |
| Right insula | 44, 16, 0 | −3.614 | < 0.001 | 2562 | 47, 48 | Right insula, right inferior frontal gyrus, opercular part |
| Left insula | −36, 16, −14 | −2.679 | < 0.001 | 1113 | 48 | Left insula, left temporal pole, superior temporal gyrus |
BD = bipolar disorder; MNI = Montreal Neurological Institute; SDM = seed-based d-mapping.
↵* Clusters that met our criteria for robustness.