Table 3

Results of the statistical tests evaluating functional connectivity between ROIs as well as the association between sleep parameters and waking DMN functional connectivity^*

									Associations with functional connectivity

		Functional connectivity			PI diagnosis		Subjective SEI		Subjective SOL		Objective SEI		Objective SOL		N3%		REM%

Pair of regions		Mean z	t	p value	F	p value	t	p value	t	p value	t	p value	t	p value	t	p value	t	p value
ACC	HC	0.20	5.56	< 0.001	1.67	0.20	−0.67	0.51	0.15	0.88	−2.61	0.014	1.09	0.29	−0.48	0.64	−1.21	0.24
ACC	IPC	0.16	4.34	< 0.001	0.43	0.52	−0.29	0.77	−0.25	0.80	−0.68	0.50	0.46	0.65	0.23	0.82	−0.69	0.50
ACC	PCC	0.49	13.87	< 0.001	0.05	0.83	−0.24	0.81	−0.80	0.43	−0.13	0.90	−0.05	0.96	−0.33	0.74	−0.40	0.70
ACC	PRC	0.20	5.45	< 0.001	1.11	0.30	−0.24	0.81	−0.81	0.42	−0.91	0.37	0.76	0.45	0.77	0.45	−0.21	0.83
ACC	RSC	0.29	9.74	< 0.001	0.02	0.88	−0.82	0.42	0.59	0.56	−1.01	0.32	2.81	0.008	−0.12	0.91	−0.20	0.84
ACC	vmPFC	0.73	26.51	< 0.001	0.37	0.55	0.27	0.79	−1.37	0.18	−0.32	0.75	1.24	0.22	0.14	0.89	−1.66	0.11
HC	IPC	0.01	0.45	0.65	0.10	0.76	−0.07	0.95	−1.24	0.22	−1.34	0.19	0.89	0.38	−0.01	0.99	−2.32	0.027
HC	PCC	0.15	4.78	< 0.001	0.08	0.78	−0.26	0.79	−0.42	0.68	−2.15	0.039	1.47	0.15	−0.10	0.92	−2.49	0.018
HC	PRC	0.07	2.44	0.020	1.19	0.28	−0.28	0.78	−0.61	0.55	−1.52	0.14	1.31	0.20	−0.28	0.78	−1.31	0.20
HC	RSC	0.38	12.41	< 0.001	0.00	0.99	−0.47	0.64	0.70	0.49	−1.96	0.06	1.54	0.13	−0.88	0.38	−1.05	0.30
HC	vmPFC	0.43	12.32	< 0.001	2.30	0.14	−1.00	0.33	1.55	0.13	−2.61	0.014	1.14	0.26	−0.73	0.47	−1.48	0.15
IPC	PCC	0.56	17.93	< 0.001	0.08	0.78	0.17	0.87	−1.30	0.20	−0.82	0.42	0.36	0.72	1.10	0.28	−1.38	0.18
IPC	PRC	0.44	13.21	< 0.001	0.12	0.73	−0.24	0.81	−0.10	0.92	0.18	0.86	0.38	0.71	1.07	0.29	0.58	0.57
IPC	RSC	0.17	5.25	< 0.001	0.03	0.85	−0.86	0.40	−0.59	0.56	−0.81	0.42	1.23	0.23	0.84	0.41	−0.96	0.35
IPC	vmPFC	0.26	8.58	< 0.001	2.27	0.14	0.52	0.61	−1.44	0.16	−0.22	0.83	0.59	0.56	0.67	0.51	−1.04	0.31
PCC	PRC	0.63	19.56	< 0.001	0.00	0.96	−0.72	0.48	−0.69	0.50	−1.10	0.28	0.21	0.84	1.80	0.08	0.74	0.46
PCC	RSC	0.52	20.68	< 0.001	0.15	0.70	−0.97	0.34	−0.27	0.79	−1.28	0.21	2.07	0.046	1.14	0.26	0.06	0.96
PCC	vmPFC	0.45	13.85	< 0.001	1.08	0.31	0.73	0.49	−0.80	0.43	0.03	0.98	0.40	0.69	−0.18	0.86	−1.84	0.08
PRC	RSC	0.63	25.50	< 0.001	0.01	0.92	−1.55	0.13	−0.29	0.77	0.44	0.66	−0.12	0.91	0.33	0.74	0.43	0.67
PRC	vmPFC	0.24	6.55	< 0.001	1.62	0.21	−0.26	0.80	−0.53	0.60	−0.40	0.69	0.36	0.73	0.39	0.70	−0.11	0.91
RSC	vmPFC	0.44	13.84	< 0.001	0.08	0.78	−1.16	0.26	0.84	0.41	−2.77	0.009	3.43	0.002	−0.35	0.73	−0.45	0.65
Network mean		0.35	15.97	< 0.001	0.15	0.70	−0.55	0.59	−0.50	0.62	−1.66	0.11	1.55	0.13	0.35	0.73	−0.12	0.23

ACC = anterior cingulate cortex; HC = hippocampus; IPC = inferior parietal cortex; N3 = slow wave sleep; PCC = posterior cingulate cortex; PI = primary insomnia; PRC = precuneus; REM = rapid eye movement sleep; RSC = retrosplenial cortex; SEI = sleep efficiency; SOL = sleep onset latency; vmPFC = ventromedial prefrontal cortex.
↵* In all tests, age, sex, BDI and STAI scores were used as covariates. Thirty-four degrees of freedom for all analyses.