Table 3

Clusters showing grey matter differences in subgroup analyses*

Cluster peak/regionsPeak MNI coordinates, x, y, zSDM Z valuep valueVoxel sizeBrodmann areaCluster breakdown
BDI v. controls
 BDI > controls
  None——————
 BDI < controls
  Right insula42, 18, −10−3.577< 0.001195447Right insula
  Left superior frontal gyrus, medial part2, 48, 32−2.698< 0.00113699, 10, 32Bilateral superior frontal gyri, medial part
  Left inferior frontal gyrus, orbital part−38, 18, −14−2.583< 0.001809Left inferior frontal gyrus
  Left anterior cingulate/paracingulate gyri0, 10, 26−1.997< 0.00162Left anterior cingulate/paracingulate gyri
BD, euthymic phase v. controls
 BD, euthymic phase > controls
  Left insula−36, −4, 181.177< 0.0012048Left insula
 BD, euthymic phase < controls
  Right inferior parietal gyri58, −50, 38−1.400< 0.0016640Right inferior parietal gyri
  Right thalamus4, −10, 12−1.484< 0.00139Right thalamus
BD, depressive phase v. controls
 BD, depressive phase > controls
  Left supplementary motor area−6, −8, 761.150< 0.001706Left supplementary motor area
 BD, depressive phase < controls
  Right insula42, 14, −4−3.523< 0.001160238, 47, 48Right insula, right temporal pole, superior temporal gyrus
  Right median cingulate/paracingulate gyri2, 6, 38−2.250< 0.00179324Right median cingulate/paracingulate gyri
BD, psychosis v. controls
 BD, psychosis > controls
  None——————
 BD, psychosis < controls
  Right superior frontal gyrus, medial part6, 56, 20−2.148< 0.00110610Right superior frontal gyrus, medial part, left anterior cingulate/paracingulate gyri, left superior frontal gyrus, medial part, right superior frontal gyrus, medial orbital
  Right precentral gyrus46, −14, 44−2.253< 0.001986Right precentral gyrus
  Left temporal pole, superior temporal gyrus−34, 8, −22−2.284< 0.0017038Left temporal pole, superior temporal gyrus

  • BD = bipolar disorder; BDI = bipolar disorder type I; MNI = Montreal Neurological Institute; SDM = seed-based d-mapping.

  • ↵* Clusters that met our criteria for robustness.