Table 2

Probes and genes that overlapped between active versus NED and active versus remitted comparisons^*

CpG	Gene	Description	Q values

			Overall ANOVA	Active v. NED	Active v. remitted
Neurotransmitter function
cg04042861	HTR2B	Serotonin system	8.66E-07	0.00760	8.47E-07
cg00968616	CUEDC1	Glutamate concentration in brain	2.94E-05	0.00375	0.000785
Physiologic and immune functions
cg00129811	DSE	Ehler-Danlos syndrome	0.000310	0.00597	0.00239
cg06350097	FCGR2A	Immune function; ulcerative colitis; rheumatoid arthritis; systemic lupus erythematosis	0.000128	0.00375	0.00653^†
cg24101945	HFM1	Ovarian insufficiency; genome integrity in germ line	9.12E-05	0.00941	0.000122
cg14666404	MCF2L2	Polycystic ovary syndrome	6.90E-05	0.00334	0.000488
cg27631389	MICAL2	Bone health	7.43E-05	0.00781	0.000201
cg18734095	NOSIP	Nitric oxide synthesis; enterocolitis	2.94E-05	0.000645	0.00236
cg17272549	EML6	Refractive astigmatism	3.17E-07	1.29E-05	1.11E-05
Nutrient metabolism
cg01423695	PRKAG2	Lipid metabolism; cholesterol biosynthsis	0.000132	0.00552	0.00128
cg22091236	RPTOR	Response to nutrient and insulin levels	0.000268	0.00707	0.00639
cg23011194	SORBS1	Insulin signalling	1.03E-05	0.00933	3.69E-06
cg08106319	ZFAND3	Insulin resistance; diabetes	1.19E-05	0.00963	3.57E-05
cg00323842	ZNF608	BMI; visceral fat	3.17E-07	8.32E-05	3.52E-05
General cellular processes
cg10095247	ANKIB1	Cellular activity	0.00201	0.00933^†	0.00867^†
cg09144769	AP2B1	Protein transport	0.00108	0.00941^†	0.00888^†
cg20124877	KPNA1	Nuclear protein import	4.76E-05	0.00552	0.000129
cg15278374	GPR133	Cellular activity	0.000852	0.00645	0.00545
cg12872357	RAB32	Mitochondrial fission	0.000397	0.00570	0.00110
cg25202261	SNX27	Protein transport	0.000840	0.00462	0.00647^†
Transcriptional activity
cg08255475	CDT1	DNA replication	2.75E-05	0.00386	0.000292
cg19161559	CUX1	Gene expression; antidepressant response	0.000752	0.00954^†	0.00404
cg14422240	FTSJD2	Methyltransferase	2.16E-06	9.33E-05	0.000609
cg03233624	MSI2	Transcriptional regulation	1.98E-05	0.000553	9.12E-05
Unspecified function
cg25197194	CCDC48	—	2.70E-06	0.00194	0.000109
cg01810593	KIAA1967	—	0.000261	0.00230	0.00649
cg18071202	LOC100292680	—	0.000343	0.00933	0.00235
cg06983052	LRRC8D	—	8.66E-07	8.32E-05	0.000141

ANOVA = analysis of variance; BMI = body mass index; NED = non-eating-disordered.
↵* Gene functions and/or associated phenotypes are obtained using the National Center for Biotechnology Information gene database. Empty cells indicate genes on which clear functions are not listed. (See Appendix 1, Table S2, available at jpn.ca/170242, for full details of effect sizes and significance levels).
↵† p < 0.05 on a probe-wise comparison after adjustment for age and smoking. Significance level is otherwise p < 0.01 when the same covariates are applied.