Table 2

Studies included in analyses of cerebrospinal fluid GABA level

StudyDiagnostic statusDisorder statenFemale sex, %Mean age, yrMain results
Gerner et al.33Unipolar and bipolarCurrent MDE245442.6Diminished GABA
Kasa et al.35Unipolar and bipolarCurrent MDE131542Diminished GABA
Mann et al.37Unipolar and bipolarCurrent MDE1675136.3Diminished GABA
Berrettini et al.53BipolarEuthymic256035No GABA level change
Post et al.50Unipolar and bipolarBefore/after treatment72941No GABA level change after carbamazepine

  • GABA = γ-aminobutyric acid; MDE = major depressive episode.