Studies included in analyses of cerebrospinal fluid GABA level
| Study | Diagnostic status | Disorder state | n | Female sex, % | Mean age, yr | Main results |
|---|---|---|---|---|---|---|
| Gerner et al. (33) | Unipolar and bipolar | Current MDE | 24 | 54 | 42.6 | Diminished GABA |
| Kasa et al. (35) | Unipolar and bipolar | Current MDE | 13 | 15 | 42 | Diminished GABA |
| Mann et al. (37) | Unipolar and bipolar | Current MDE | 167 | 51 | 36.3 | Diminished GABA |
| Berrettini et al. (53) | Bipolar | Euthymic | 25 | 60 | 35 | No GABA level change |
| Post et al. (50) | Unipolar and bipolar | Before/after treatment | 7 | 29 | 41 | No GABA level change after carbamazepine |
GABA = γ-aminobutyric acid; MDE = major depressive episode.