Table 2

Detailed scan acquisition parameters for structural MRI sequences

CAN-BIND site	Toronto Western/Toronto General Hospital	Centre for Addiction and Mental Health	McMaster University	University of Calgary	University of British Columbia	Sunnybrook Health Sciences Centre	Queen’s University	Saint Michael’s Hospital
CAN-BIND project	CAN-BIND-1	CAN-BIND-1	CAN-BIND-1	CAN-BIND-1	CAN-BIND-1	CAN-BIND-3	CAN-BIND-1	CAN-BIND-5
	CAN-BIND-2	CAN-BIND-2		CAN-BIND-3	CAN-BIND-2		CAN-BIND-4	CAN-BIND-10
							CAN-BIND-9
Scanner model	GE 3.0 T	GE 3.0 T	GE 3.0 T	GE 3.0 T	Phillips 3.0 T	Phillips 3.0 T	Siemens 3.0 T	Siemens 3.0 T
	Signa HDxt	Discovery MR750	Discovery MR750	Discovery MR750	Intera	Achieva	TrioTim	Skyra
Software version	HD16.0_V02_1131.a	DV24.0_R01_1344.a	DV25.0_R02_1549.b	DV25.0_R02_1549.b	3.2.3, 3.2.3.1	3.2.2, 3.2.2.0	syngo MR B19	syngo MR E11
Coil	GE 8HRBRAIN	GE 8HRBRAIN	GE 32Ch Head/GE HNS Head	GE HNS Head	SENSE-Head-8	SENSE-Head-8	12-channel head matrix coil	20-channel head/neck coil
T₁-weighted scan, sagittal acquisition
Repetition time, ms	7.5^a	6.4^b	6.4^b	6.4^b	6.57	6.50	1760^c	1840
Echo time, ms	2.86^d	2.8^e	2.8^e	2.8^e	2.9^f	3.0	2.2^g	3.4
Inversion time, ms	450	450	450	450	950	950	950^h	950
Flip angle, degrees	15	15	15	15	8	8	15	15
Pixel bandwidth	260ⁱ	260ⁱ	260^j	260ⁱ	241^k	241	199	200
Matrix dimension, pixels	240 × 240^l	240 × 240^l	240 × 240^l	240 × 240^l	240 × 240^m	240 × 240	256 × 256	256 × 256
Voxel dimension, mm	1 × 1 × 1	1 × 1 × 1	1 × 1 × 1	1 × 1 × 1	1 × 1 × 1	1 × 1 × 1	1 × 1 × 1	1 × 1 × 1
Slices, n	176	180ⁿ	180ⁿ	180ⁿ	180^o	155	192	176
Acquisition times, min	03:40	03:30	03:30	03:30	09:50	09:53	04:06	07:53
Diffusion tensor imaging
Repetition time, ms	8000^p	8000^p	8000^p	8000^p	9000^p	8999	8000^p	8200
Echo time, ms	94^q	94^q	94^q	94^q	94^q	94	94^q	94
Flip angle, degrees	90	90	90	90	90	90	90	90
Pixel bandwidth	5208^r	5208^r	5208	5208^s	3326^t	3256	2894^u	1410
Matrix dimension, pixels	96 × 96	96 × 96	96 × 96	96 × 96	96 × 96	96 × 96	96 × 96	96 × 96
Voxel dimension, mm	2.5 × 2.5 × 2.5	2.5 × 2.5 × 2.5	2.5 × 2.5 × 2.5	2.5 × 2.5 × 2.5^v	2.5 × 2.5 × 2.5^w	2.4 × 2.4 × 2.4	2.5 × 2.5 × 2.5	2.5 × 2.5 × 2.5
Diffusion directions, n	31	31	31	31	30	32	30	30
Diffusion b value	1000	1000	1000	1000 (CAN-BIND-1); 1000 and 2500 (CAN-BIND-3)	1000	1000 and 2500	1000	1000
Diffusion images with b = 0	6	6	6	6	6	6	6	6
Acquisition times, min	05:04	05:04	05:04	5:04 (CAN-BIND-1); 7:12 and 7:12 (CAN-BIND-3)	04:57	5:15 and 5:15	04:34	04:40
T₂-weighted proton density scan, axial acquisition
Repetition time, ms	6583^x	5724^y	6004^z	6004^aa	5500	5428	11900^bb	NA
Echo time 1, ms	7.3	7.5	7.5	7.5	16.8	16.8	8.1	NA
Echo time 2, ms	87.8^cc	90.3	90.3	90.3	88.0	88.0	105.0	NA
Flip angle, degrees	90	125	125	125	125	125	125	NA
Pixel bandwidth	326	326	326	326	188	188	326	NA
Matrix dimension, pixels	192 × 192	192 × 192	192 × 192	192 × 192	192 × 192	192 × 138	192 × 168	NA
Voxel dimension, mm	1.25 × 1.25 × 2.5	1.25 × 1.25 × 2.5	1.25 × 1.25 × 2.5	1.25 × 1.25 × 2.5	1.25 × 1.25 × 2.5	1.25 × 1.37 × 2.5	1.25 × 1.25 × 2.5	NA
Slices, n	116	116	116	116	116	116	116	NA
Acquisition times, min	01:47	01:32	01:27	01:30	04:35	02:23	01:47	NA

CAN-BIND = Canadian Biomarker Integration Network in Depression; NA = not applicable.
↵a For n = 42, the repetition time for GE Signa was 7.2 ms.
↵b For n = 59, the repetition time for GE Discovery ranged from 7.2 ms to 7.7 ms.
↵c For n = 11, the repetition time for Siemens was 1900 ms.
↵d For n = 42, the echo time for GE Signa was 2.7 ms.
↵e For n = 59, the echo time for GE Discovery ranged from 2.7 ms to 2.9 ms.
↵f For n = 27, the echo time for Philips Achieva was 3.6 ms.
↵g For n = 11, the echo time for Siemens was 2.7 ms.
↵h For n = 11, the inversion time for Siemens was 900 ms.
↵i For n = 78, the pixel bandwidth for GE was 244.
↵j For n = 23, the pixel bandwidth for GE was 122.
↵k For n = 27, the pixel bandwidth for Philips was 191.
↵l For n = 91, the matrix dimensions for GE were 220 × 220.
↵m For n = 27, the matrix dimensions for Phillips were 256 × 256.
↵n For n = 49, the number of slices for GE Discovery was 176.
↵o For n = 27, the number of slices for Philips was 170.
↵p For n = 139, the repetition time was 14 000 ms. The repetition time for diffusion tensor imaging was adjusted to be consistent (reduced to 8000 ms for GE scanners and 8999/9000 ms for Philips scanners) early in CAN-BIND-1.
Subsequent CAN-BIND studies used the reduced repetition time.
↵q For n = 145, the echo time for diffusion tensor imaging sequences ranged from 78 to 85 ms.
↵r For n = 49, the pixel bandwidth for GE was 3906.
↵s For n = 19, the pixel bandwidth was 1953.
↵t For n = 27, the pixel bandwidth was 3256.
↵u For n = 11, the pixel bandwidth was 1408.
↵v For n = 19, the voxel dimensions was 0.9 × 0.9 × 2.5.
↵w For n = 27, the voxel dimension was 2.4 × 2.4 × 2.4.
↵x For n = 42, the repetition time was 7167 ms.
↵y For n = 7, the repetition time was 5794 ms.
↵z For n = 23, the repetition time was 5921 ms.
↵aa For n = 19, the repetition time was 6064 ms.
↵bb For n = 11, the repetition time was 11 670 ms.
↵cc For n = 42, the echo time was 88.32 ms.