CAN-BIND study* | CAN-BIND-1† | CAN-BIND-2 | CAN-BIND-3 | CAN-BIND-4 | CAN-BIND-5 | CAN-BIND-9 | CAN-BIND-10 |
---|---|---|---|---|---|---|---|
Characteristic | Drug | rTMS | At-risk youth | Stress and reward | Suicide markers | Cognitive remediation | TBI |
Patient-specific information, diagnosis | MDD | MDD | Youth at risk for severe mental illness; family high risk | MDD | MDD, MDD with suicidal ideation or attempt | MDD | MDD, TBI, MDD + TBI |
Intervention/treatment | SSRI (escitalopram); aripiprazole | rTMS | NA | NA | NA | Cognitive remediation therapy | NA |
Patients, n | 211 | 205 | 200 | 100 | 90 | 75 | 100 |
Controls, n | 112 | NA | 40 | 100 | 30 | NA | 25 |
Number of times scanned | 3 | 2 | 3 | 2 | 2 | 3 | 1 |
T1 structural* | ♦ | ♦ | ♦ | ♦ | ♦ | ♦ | ♦ |
Diffusion tensor imaging | ♦ | ♦ | ♦ | ♦ | ♦ | ♦ | ♦ |
Resting-state fMRI | ♦ | ♦ | ♦ | ♦ | ♦ | ♦ | ♦ |
Go/no-go task | ♦ | ♦ | ♦ | ♦ | ♦ | ||
Incentive delay task | ♦ | ♦ | ♦ | ♦ | |||
Working memory task | ♦ | ♦ | |||||
Breath-holding challenge/breath-hold task | ♦ | ♦ | |||||
Shifted attention emotion appraisal test | ♦ | ||||||
Probabilistic reward task | ♦ | ||||||
Prediction error task | ♦ | ||||||
Social cognition task | ♦ | ||||||
Other | Face categorization task | Arterial spin labelling |
CAN-BIND = Canadian Biomarker Integration Network in Depression; MDD = major depressive disorder; NA = not applicable; rTMS = repetitive transcranial magnetic stimulation; SSRI = selective serotonin reuptake inhibitor; TBI = traumatic brain Injury.
↵* Overall, the 7 studies are projected to include approximately 980 patients and 305 controls, for a total of approximately 3000 T1 scans.
↵† Approximately 600 patient T1 scans, approximately 300 control T1 scans.