Table 1

Overview of CAN-BIND studies highlighting common, standardized data elements

CAN-BIND study^*	CAN-BIND-1^†	CAN-BIND-2	CAN-BIND-3	CAN-BIND-4	CAN-BIND-5	CAN-BIND-9	CAN-BIND-10
Characteristic	Drug	rTMS	At-risk youth	Stress and reward	Suicide markers	Cognitive remediation	TBI
Patient-specific information, diagnosis	MDD	MDD	Youth at risk for severe mental illness; family high risk	MDD	MDD, MDD with suicidal ideation or attempt	MDD	MDD, TBI, MDD + TBI
Intervention/treatment	SSRI (escitalopram); aripiprazole	rTMS	NA	NA	NA	Cognitive remediation therapy	NA
Patients, n	211	205	200	100	90	75	100
Controls, n	112	NA	40	100	30	NA	25
Number of times scanned	3	2	3	2	2	3	1
T₁ structural^*	♦	♦	♦	♦	♦	♦	♦
Diffusion tensor imaging	♦	♦	♦	♦	♦	♦	♦
Resting-state fMRI	♦	♦	♦	♦	♦	♦	♦
Go/no-go task	♦	♦	♦	♦		♦
Incentive delay task	♦	♦	♦	♦
Working memory task			♦			♦
Breath-holding challenge/breath-hold task					♦		♦
Shifted attention emotion appraisal test					♦
Probabilistic reward task					♦
Prediction error task							♦
Social cognition task			♦
Other	Face categorization task		Arterial spin labelling

CAN-BIND = Canadian Biomarker Integration Network in Depression; MDD = major depressive disorder; NA = not applicable; rTMS = repetitive transcranial magnetic stimulation; SSRI = selective serotonin reuptake inhibitor; TBI = traumatic brain Injury.
↵* Overall, the 7 studies are projected to include approximately 980 patients and 305 controls, for a total of approximately 3000 T₁ scans.
↵† Approximately 600 patient T₁ scans, approximately 300 control T₁ scans.