Table 1

Transmitted and nontransmitted truncating alleles found in 20 singleton high-functioning autism families

	Total^*	Transmitted	Nontransmitted	MeanProp^†	p value
Truncating alleles
Probands (n = 20)	247	117	130	47%	0.78
Unaffected siblings (n = 9)	111	46	65	42%	0.64
Truncating alleles (brain-expressed)
Probands (n = 20)	144	71	73	49%	0.93
Unaffected siblings (n = 9)	59	25	34	43%	0.66

↵* Total number of truncating alleles in parents.
↵† Average of proportion of transmitted alleles from parents to probands with high-functioning autism or unaffected siblings.