Table 4

LRP1 burden analysis of ultra-rare variants in autism-spectrum disorder and schizophrenia*

GroupIndividualsPathogenic ultra-rare variantsp value
Autism-spectrum disorder1778351.2 × E−05
  • * Total individuals used across different sequencing data sets and number of ultra-rare variants predicted to be pathogenic. The selection of variants includes missense, truncating variants and splice-site variants (full list of ultra-rare variants in Appendix 1, Table S11, available at

  • Whole-exon sequencing from the Sweden Schizophrenia Population-Based Case–Control data set (dbGAP accession: phs000473.v2.p2).

  • ARRA Autism Sequencing Collaboration (dbGAP accession: phs000298.v3.p2).