Classification of treatment response for obsessive–compulsive, depressive and anxiety symptoms
| Treatment response | Definition |
|---|---|
| Obsessive-compulsive | |
| Responder | Y-BOCS reduction ≥ 35% relative to the baseline score + CGI-I 1 (very much improved) or 2 (much improved) |
| Partial responder | Y-BOCS reduction 25%–35% + CGI-I ≥ 3 (minimally improved) |
| Remission | Y-BOCS ≤ 12 + CGI-S 1 (normal, not at all ill) or 2 (borderline mentally ill) ≥ 1 week |
| Depressive | |
| Responder | HAM-A reduction ≥ 50% relative to the baseline score |
| Remission | HAM-A ≤ 7 |
| Anxiety | |
| Responder | HAM-D reduction ≥ 50% relative to the baseline score |
| Remission | HAM-D ≤ 7 |
CGI-I = Clinical Global Impression–Improvement; CGI-S = Clinical Global Impression–Severity; HAM-A = Hamilton Rating Scale for Anxiety; HAM-D = Hamilton Rating Scale for Depression; Y-BOCS = Yale–Brown Obsessive Compulsive Scale.