Table 3

Group comparison using link-based controlling procedure, controlled for age, sex and handedness*

Negative correlation between symptom scores and FA values
BDISTAI-TCDSSignificant components DPD ≠ HCpFDR value
Left temporal pole − − Left superior temporal gyrus< 0.001
Right middle temporal gyrus − − Right supramarginal gyrus0.002
Brain stem − − Left caudate< 0.001
Right medial OFC − − Right caudal ACC0.001
Right inferior temporal gyrus − − Right lingual cortex< 0.001
Right superior temporal gyrus + + Right banks of superior temporal sulcus< 0.01
Left insula − − Left pars triangularis − − Left lateral OFC< 0.01
Left caudal ACC − − Left medial OFC + + Right superior frontal gyrus< 0.01
Left isthmus of the cingulate cortex + + Right cuneus + + Left superior parietal cortex< 0.01
  • ACC = anterior cingulate cortex; BDI = Beck Depression Inventory; CDS = Cambridge Depersonalization Scale; DPD = depersonalization/derealization disorder; FA = fractional anisotropy; FDR = false discovery rate; HC = healthy controls; STAI-T = State-Trait Anxiety Scale, trait version; OFC = orbitofrontal cortex.

  • * All components for which patients with DPD and controls displayed significantly different FA values are listed along with the respective p value. Ticks mark components for which a significant correlation was found with dissociative symptoms scores (CDS-30), trait anxiety (STAI-T), or depression (BDI).

  • Minus signs between brain regions (− −) represent connections for which patients with DPD displayed lower FA values than controls; plus signs between regions (+ +) represent connections for which patients displayed higher FA values than controls.