Individual clinical symptom measures after MRgFUS, 24-month follow-up (part 1 of 2)
| Measure | Pt. no. | BL | 1 wk | 1 mo | 3 mo | 6 mo | 12 mo | 24 mo | IR at 6 mo, % | IR at 12 mo, % | IR at 24 mo, % |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Y-BOCS* | 1 | 38 | 36 | 35 | 32 | 29 | 18 | 21 | 23.7 | 52.6 | 44.7 |
| 2 | 34 | 32 | 27 | 18 | 18 | 22 | 27 | 47.1 | 35.3 | 20.6 | |
| 3 | 35 | 31 | 32 | 28 | 26 | 15 | 14 | 25.7 | 57.1 | 60.0 | |
| 4 | 34 | 28 | 22 | 22 | 21 | 22 | 19 | 38.2 | 35.3 | 44.1 | |
| 5 | 37 | 35 | 29 | 28 | 27 | 28 | 30 | 27.0 | 24.3 | 18.9 | |
| 6 | 35 | 28 | 29 | 24 | 23 | 20 | 14 | 34.3 | 42.9 | 60.0 | |
| 7 | 34 | 20 | 18 | 21 | 16 | 23 | 21 | 52.9 | 32.4 | 38.2 | |
| 8 | 36 | 33 | 30 | 28 | 29 | 27 | 26 | 19.4 | 25.0 | 27.8 | |
| 9 | 30 | 30 | 28 | 27 | 27 | 21 | 21 | 10.0 | 30.0 | 30.0 | |
| 10 | 34 | 30 | 30 | 27 | 19 | 15 | 12 | 44.1 | 55.9 | 64.7 | |
| 11 | 31 | 30 | 30 | 30 | 25 | 29 | 29 | 19.4 | 6.5 | 6.5 | |
| Mean ± SD | 34.4 ± 2.3 | 30.3 ± 4.3 | 28.2 ± 4.6 | 25.9 ± 4.2 | 23.6 ± 4.5 | 21.8 ± 4.8 | 21.3 ± 6.2 | 31.1 ± 13.3 | 36.1 ± 15.3 | 37.8 ± 18.9 | |
| HAM-D† | 1 | 27 | 7 | 5 | 7 | 4 | 4 | 7 | 85.2 | 85.2 | 74.1 |
| 2 | 18 | 15 | 8 | 11 | 11 | 21 | 15 | 38.9 | −16.7 | 16.7 | |
| 3 | 25 | 11 | 13 | 12 | 11 | 6 | 3 | 56.0 | 76.0 | 88.0 | |
| 4 | 20 | 10 | 6 | 10 | 9 | 6 | 5 | 55.0 | 70.0 | 75.0 | |
| 5 | 24 | 10 | 5 | 9 | 15 | 14 | 15 | 37.5 | 41.7 | 37.5 | |
| 6 | 19 | 11 | 10 | 11 | 9 | 5 | 2 | 52.6 | 73.7 | 89.5 | |
| 7 | 17 | 9 | 5 | 10 | 11 | 13 | 14 | 35.3 | 23.5 | 17.6 | |
| 8 | 13 | 10 | 8 | 6 | 8 | 10 | 1 | 38.5 | 23.1 | 92.3 | |
| 9 | 16 | 8 | 10 | 11 | 9 | 3 | 9 | 43.8 | 81.3 | 43.8 | |
| 10 | 9 | 6 | 9 | 6 | 2 | 6 | 3 | 77.8 | 33.3 | 66.7 | |
| 11 | 21 | 13 | 12 | 16 | 10 | 10 | 10 | 52.4 | 52.4 | 52.4 | |
| Mean ± SD | 19.0 ± 5.3 | 10.0 ± 2.6 | 8.3 ± 2.8 | 9.9 ± 2.9 | 9.0 ± 3.5 | 8.9 ± 5.4 | 7.6 ± 5.3 | 52.1 ± 16.4 | 49.4 ± 31.8 | 59.4 ± 27.7 | |
| HAM-A‡ | 1 | 34 | 5 | 6 | 6 | 4 | 4 | 7 | 88.2 | 88.2 | 79.4 |
| 2 | 17 | 14 | 7 | 7 | 7 | 19 | 15 | 58.8 | −11.8 | 11.8 | |
| 3 | 31 | 13 | 16 | 15 | 17 | 6 | 7 | 45.2 | 80.6 | 77.4 | |
| 4 | 26 | 9 | 7 | 8 | 5 | 4 | 5 | 80.8 | 84.6 | 80.8 | |
| 5 | 19 | 10 | 8 | 8 | 5 | 15 | 14 | 73.7 | 21.1 | 26.3 | |
| 6 | 21 | 9 | 11 | 12 | 13 | 6 | 2 | 38.1 | 71.4 | 90.5 | |
| 7 | 17 | 10 | 9 | 14 | 8 | 12 | 10 | 52.9 | 29.4 | 41.2 | |
| 8 | 20 | 8 | 10 | 14 | 8 | 9 | 7 | 60.0 | 55.0 | 65.0 | |
| 9 | 20 | 9 | 19 | 18 | 8 | 5 | 7 | 60.0 | 75.0 | 65.0 | |
| 10 | 16 | 7 | 11 | 6 | 3 | 5 | 4 | 81.3 | 68.8 | 75.0 | |
| 11 | 25 | 20 | 22 | 21 | 15 | 9 | 9 | 40.0 | 64.0 | 64.0 | |
| Mean ± SD | 22.4 ± 5.9 | 10.4 ± 4.1 | 11.5 ± 5.3 | 11.3 ± 5.1 | 8.5 ± 4.6 | 8.6 ± 4.9 | 7.9 ± 3.9 | 61.7 ± 17.3 | 56.9 ± 31.3 | 61.5 ± 24.7 | |
| GAF§ | 1 | 30 | — | — | 40 | 40 | 53 | 55 | 33.3 | 76.7 | 83.3 |
| 2 | 35 | — | — | 45 | 45 | 36 | 42 | 28.6 | 2.9 | 20.0 | |
| 3 | 30 | — | — | 40 | 43 | 69 | 69 | 43.3 | 130.0 | 130.0 | |
| 4 | 33 | — | — | 43 | 51 | 55 | 55 | 54.6 | 66.7 | 66.7 | |
| 5 | 32 | — | — | 40 | 40 | 37 | 40 | 25.0 | 15.6 | 25.0 | |
| 6 | 33 | — | — | 45 | 45 | 60 | 65 | 36.4 | 81.8 | 97.0 | |
| 7 | 42 | — | — | 48 | 58 | 55 | 55 | 38.1 | 31.0 | 31.0 | |
| 8 | 39 | — | — | 43 | 43 | 48 | 50 | 10.3 | 23.1 | 28.2 | |
| 9 | 43 | — | — | 51 | 55 | 65 | 65 | 27.9 | 51.2 | 51.2 | |
| 10 | 35 | — | — | 47 | 60 | 65 | 70 | 71.4 | 85.7 | 100.0 | |
| 11 | 42 | — | — | 45 | 48 | 50 | 50 | 14.3 | 19.0 | 19.0 | |
| Mean ± SD | 35.8 ± 4.9 | — | — | 44.3 ± 3.6 | 48.0 ± 7.1 | 53.9 ± 10.8 | 56.0 ± 10.3 | 34.8 ± 17.4 | 53.1 ± 38.8 | 59.2 ± 38.6 | |
| CGI-S¶ | 1 | 7 | 7 | 7 | 5 | 5 | 4 | 4 | — | — | — |
| 2 | 6 | 6 | 5 | 4 | 4 | 4 | 5 | — | — | — | |
| 3 | 6 | 6 | 6 | 5 | 4 | 3 | 3 | — | — | — | |
| 4 | 6 | 5 | 4 | 4 | 4 | 4 | 4 | — | — | — | |
| 5 | 7 | 7 | 6 | 5 | 5 | 5 | 5 | — | — | — | |
| 6 | 6 | 5 | 5 | 4 | 4 | 4 | 3 | — | — | — | |
| 7 | 7 | 5 | 4 | 4 | 4 | 4 | 4 | — | — | — | |
| 8 | 6 | 6 | 6 | 5 | 5 | 4 | 4 | — | — | — | |
| 9 | 5 | 5 | 5 | 4 | 4 | 4 | 4 | — | — | — | |
| 10 | 6 | 5 | 6 | 4 | 4 | 3 | 2 | — | — | — | |
| 11 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | — | — | — | |
| Mean ± SD | 6.1 ± 0.2 | 5.6 ± 0.2 | 5.4 ± 0.3 | 4.5 ± 0.2 | 4.4 ± 0.2 | 4.0 ± 0.2 | 3.9 ± 0.3 | — | — | — | |
| CGI-I** | 1 | — | 4 | 4 | 3 | 3 | 1 | 2 | — | — | — |
| 2 | — | 4 | 3 | 2 | 2 | 2 | 3 | — | — | — | |
| 3 | — | 3 | 4 | 2 | 2 | 1 | 1 | — | — | — | |
| 4 | — | 3 | 2 | 2 | 2 | 2 | 2 | — | — | — | |
| 5 | — | 4 | 3 | 3 | 3 | 3 | 3 | — | — | — | |
| 6 | — | 3 | 3 | 2 | 2 | 2 | 1 | — | — | — | |
| 7 | — | 2 | 1 | 2 | 1 | 2 | 2 | — | — | — | |
| 8 | — | 4 | 4 | 3 | 3 | 2 | 2 | — | — | — | |
| 9 | — | 4 | 4 | 4 | 3 | 2 | 2 | — | — | — | |
| 10 | — | 2 | 3 | 3 | 2 | 1 | 1 | — | — | — | |
| 11 | — | 4 | 4 | 4 | 4 | 4 | 4 | — | — | — | |
| Mean ± SD | — | 3.4 ± 0.2 | 3.2 ± 0.3 | 2.7 ± 0.2 | 2.5 ± 0.2 | 2.0 ± 0.3 | 2.1 ± 0.3 | — | — | — |
BL = baseline; CGI-I = Clinical Global Impression–Improvement; CGI-S = Clinical Global Impression–Severity; GAF = Global Assessment of Functioning; HAM-A = Hamilton Rating Scale for Anxiety; HAM-D = Hamilton Rating Scale for Depression; IR = improvement rate; MRgFUS, magnetic resonance–guided focused ultrasound; SD = standard deviation; Y-BOCS = Yale–Brown Obsessive Compulsive Disorder Scale.
↵* Mean Y-BOCS scores decreased significantly across the 24-month follow-up period (linear mixed model; F6,10.0 = 18.6, p < 0.001).
↵† Mean HAM-D scores decreased significantly across the 24-month follow-up period (linear mixed model; F6,10.0 = 13.4, p < 0.001).
↵‡ Mean HAM-A scores decreased significantly across the 24-month follow-up period (linear mixed model; F6,10.0 = 85.4, p < 0.001).
↵§ Mean GAF scores increased significantly across the 24-month follow-up period (linear mixed model; F4,10.0 = 25.2, p < 0.001).
↵¶ Mean CGI-S scores decreased significantly across the 24-month follow-up period (linear mixed model; F6,10.0 = 11.3, p = 0.001).
↵** Mean CGI-I scores decreased significantly across the 24-month follow-up period (linear mixed model; F5,10.0 = 13.3, p < 0.001).