Table 2

The effect of sex and suicide (schizophrenia only) on levels of muscarinic receptor–positive neurons, total neurons and total glia in Brodmann areas 9 and 17, medial dorsal nucleus and regions of the hippocampus^*

			Sex					Suicide

Region	Layer		Male	Female	t	d.f.	p value	Suicide	Non-suicide	t	d.f.	p value
BA9	Layer III	CHRM1+ neurons	841 ± 77	680 ± 158	1.00	34	0.32	510 ± 116	697 ± 81	1.28	22	0.21
		Total neurons	1392 ± 70	1604 ± 37	1.70	34	0.10	1407 ± 117	1422 ± 98	0.09	22	0.93
		Total glia	2187 ± 156	2438 ± 103	0.89	34	0.37	2008 ± 267	2290 ± 214	0.75	22	0.46
	Layer V	CHRM1+ neurons	1016 ± 98	882 ± 175	0.68	34	0.50	624 ± 151	817 ± 99	1.06	22	0.30
		Total neurons	1541 ± 58	1566 ± 73	0.22	34	0.82	1407 ± 70	1525 ± 59	1.14	22	0.27
		Total glia	2172 ± 136	2391 ± 80	0.91	34	0.36	2191 ± 263	2152 ± 161	0.13	22	0.90
BA17	Layer III	CHRM1+ neurons	805 ± 101	543 ± 137	1.35	34	0.18	578 ± 200	547 ± 80	0.17	22	0.86
		Total neurons	1701 ± 87	1629 ± 91	0.45	34	0.66	1590 ± 257	1662 ± 96	0.75	22	0.74
		Total glia	2355 ± 166	2671 ± 114	1.06	34	0.30	2135 ± 396	2421 ± 197	0.72	22	0.48
	Layer V	CHRM1+ neurons	473 ± 83	354 ± 109	0.75	34	0.45	335 ± 73	254 ± 34	0.26	22	0.26
		Total neurons	1312 ± 64	1192 ± 64	1.02	34	0.32	1320 ± 158	1197 ± 66	0.86	22	0.40
		Total glia	2297 ± 64	2896 ± 191	1.96	34	0.06	2180 ± 453	2471 ± 192	0.7	22	0.49
MDN		CHRM1+ neurons	478 ± 45	454 ± 45	0.58	34	0.56	374 ± 21	502 ± 23	3.33	22	0.003
		Total neurons	596 ± 30	544 ± 52	0.88	34	0.39	477 ± 34	619 ± 37	2.26	22	0.03
		Total glia	2777 ± 170	2847 ± 266	0.22	34	0.83	2438 ± 331	3054 ± 2303	1.47	22	0.15
Hippocampus	CA3	CHRM1+ neurons	193 ± 33	155 ± 52	0.62	16	0.540	213 ± 72	132 ± 32	1.20	11	0.25
		Total neurons	350 ± 12	379 ± 14	1.33	16	0.200	363 ± 20	349 ± 13	0.59	11	0.56
		Total glia	1477 ± 56	1315 ± 185	1.13	16	0.270	1416 ± 180	1396 ± 95	0.11	11	0.91
	CA2	CHRM1+ neurons	153 ± 35	179 ± 63	0.37	16	0.720	151 ± 36	129 ± 40	0.33	11	0.75
		Total neurons	441 ± 37	534 ± 37	2.84	16	0.010	452 ± 35	465 ± 29	0.27	11	0.79
		Total glia	1647 ± 52	1462 ± 154	1.48	16	0.160	1584 ± 176	1581 ± 85	0.01	11	0.99
	CA1	CHRM1+ neurons	44 ± 8.1	27 ± 12	1.12	16	0.280	36 ± 16	33 ± 8.9	0.17	11	0.86
		Total neurons	384 ± 15	442 ± 23	4.53	16	0.0003	440 ± 13	410 ± 21	0.38	11	0.39
		Total glia	1096 ± 46	959 ± 90	0.16	16	0.160	1057 ± 81	1100 ± 66	0.38	11	0.71
	Poly	CHRM1+ neurons	116 ± 20	117 ± 39	0.01	16	0.990	110 ± 45	94 ± 22	0.36	11	0.72
		Total neurons	210 ± 11	272 ± 16	2.96	16	0.009	223 ± 28	237 ± 17	0.43	11	0.68
		Total glia	1579 ± 66	1393 ± 112	3.19	16	0.006	1576 ± 159	1467 ± 72	0.73	11	0.48

BA = Brodmann area; CA = cornu ammonis; CHRM1+ = muscarinic M1 receptor–positive; MDN = medial dorsal nucleus; poly = polymorphic layer of the dentate gyrus; SEM = standard error of the mean.
↵* All data listed as mean ± SEM of cells per mm³ × 10⁻².