Single nucleotide polymorphisms in scaffolding genes associated with schizophrenia, autism-spectrum disorders and other clinical phenotypes of interest
| Gene | Single nucleotide polymorphisms | Sources | |||
|---|---|---|---|---|---|
| Schizophrenia | Austism-spectrum disorders | Schizophrenia and autism-spectrum disorders | Other associated phenotypes | ||
| DLG1 | rs382579, rs2122824, rs7616588, rs7638423, rs6805929, rs2044862, rs4916461, rs338187, rs10489880 (109) rs9843659 (109), (110) | — | — | — | Sato et al. (109) Uezato et al. (110) |
| DLG3 | — | ss104807047, rs28391150, rs1886890, rs3215810, rs41303736, ss104807048 (111) | — | rs28391150 (associated with intellectual disability) (83) ss104807047 (associated with intellectual disability) (84) | Zanni et al. (83) Philips et al. (84) Kantojärvi et al. (111) |
| DLG4 | rs2230178, rs6145976, rs2017365, rs739669, rs13333 (112) rs222837 (113) rs390200, rs222853, rs17203281 (112), (113) | — | — | — | Cheng et al. (112) Balan et al. (113) |
| DLGAP1 | rs145691437, rs3786431, rs201567254, rs3745051, rs11662259 (114) | — | — | — | Li et al. (114) |
| DLGAP2 | rs2906568, rs2293909 (116) | — | rs2906569, rs2301963 (115), (116) | rs2301963 (associated with decreased orbitofrontal cortex white matter volume) (117) | Chien et al. (115) Li et al. (116) Wu et al. (117) |
| SHANK3 | — | rs9616915 (118), (119) Independent studies did not find association with autism spectrum disorder (120), (121) | — | — | Shao et al. (118) Mashayekhi (119) Sykes et al. (120) Qin et al. (121) |
| HOMER1 | rs4704560, rs2290639 (122) rs9293785 (123) | — | — | rs4704560 C allele (associated with hallucinations in patients with Parkinson’s disease) (124) rs2290639 (associated with substance abuse) (125) | Spellmann et al. (122) Zhao et al. (123) De Luca et al. (124) Strauss et al. (125) |
| HOMER2 | rs2306428, rs86949, SNP20 (126) | — | — | — | Gilks et al. (126) |
SNP = single nucleotide polymorphism.