Grey-matter volume regions of interest, associations with well-being and resilience*
| Effect/region | Side | Coordinates, MNI | Cluster size, mm3 | t | pFDR | ||
|---|---|---|---|---|---|---|---|
| x | y | z | |||||
| Well-being: negative correlation/pons (brainstem) | Right | 9 | −16 | −35 | 4244 | 4.66 | 0.039† |
| Resilience: negative correlation/pons (brainstem) | Right | 6 | −13 | −33 | 5120 | 4.70 | 0.013† |
| Depression/anxiety: positive correlation/pons (brainstem) | Left | −2 | −16 | −23 | 3471 | 3.86 | 0.058 |
FDR = false discovery rate; MNI = Montreal Neurological Institute; VBM = voxel-based morphometry.
↵* Analyses conducted in twin 1, controlling for age and sex. Verification of results in twin 2 was conducted using linear mixed models for significant extracted clusters in SPSS (p < 0.05, corrected). The well-being and depression/anxiety VBM analysis was conducted in all twin 1 participants (n = 132). For the resilience VBM analysis, associations between grey-matter volume and well-being scores were evaluated in the early-life stress group (n = 97). Trend effects for other regions of interest at uncorrected levels are provided in Appendix 1.
↵† Result is significant at pFDR < 0.05 (cluster-level).