Results from cross-sectional and longitudinal analyses, mean diffusivity*
| Voxels, no. | Max 1 – p | MNI x, y, z (mm) |
|---|---|---|
| Cross-sectional results | ||
| Baseline | ||
| MDD > healthy controls | ||
| 6526 | 0.964 | −35, 8, 20 |
| 3266 | 0.955 | 19, 22, 38 |
| Healthy controls > MDD, no significant results | ||
| Follow-up | ||
| MDD > healthy controls, no significant results | ||
| Healthy controls > MDD, no significant results | ||
| Longitudinal results | ||
| Healthy controls | ||
| Follow up > baseline | ||
| 4048 | 0.003 | −14, 35, 6 |
| 1342 | 0.97 | 32, 34, 6 |
| 2 | 0.95 | 4, 28, 11 |
| Baseline > follow-up, no significant results | ||
| MDD | ||
| Follow-up > baseline, no significant results | ||
| Baseline > follow-up, no significant results | ||
MDD = major depressive disorder; MNI = Montreal Neurological Institute.
↵* Dimensions of clusters (number of voxels) and localization of signal peaks (MNI coordinates) are given for regions showing maximal differences in tract-based spatial statistics values (signal peak).