Table 3

Results of association tests for genome-wide significant variants in the discovery sample

Variant	Chr	Pos	Ref	Alt	Gene	Childhood environmental factors	Main genetic effect					Environment-moderated genetic effect

							Disc		Rep		Meta p	Disc		Rep		Meta p

							β	p	β	p		β	p	β	p
DSM-5 diagnostic criterion count, African Americans
rs10188036	2	202256694	T	C	TRAK2	Change in residence	−1.05	4.05 × E⁻⁵	−0.86	0.09	1.13 × E⁻⁵	−1.89	1.77 × E⁻⁸	−0.97	0.12	2.95 × E⁻⁸^†
del-13:61274071^*	13	61274071	AT	A	LINC00378	Household drinking and illicit drug use	−1.55	2.75 × E⁻⁶	—	—	—	−2.71	4.94 × E⁻⁸	—	—	—
Membership likelihood for subtype 5, African Americans
del-1:15511771	1	15511771	CTG	C	TMEM51	Nontraditional parental care	0.15	2.16 × E⁻⁸	0.06	0.18	3.77 × E⁻⁸	0.23	3.61 × E⁻¹⁰	0.10	0.10	9.11 × E⁻¹⁰^†
rs149843442	1	82524289	G	A	LPHN2	Household tobacco use	0.14	7.45 × E⁻⁶	0.14	8.25 × E⁻³	1.98 × E⁻⁷	0.23	3.92 × E⁻⁸	0.11	0.09	3.50 × E⁻⁸^†
rs114492924	5	173935380	C	T	LINC01411	Change in residence	0.13	1.71 × E⁻⁴	0.13	5.71 × E⁻³	3.47 × E⁻⁶	0.27	1.23 × E⁻⁸^†	0.16	3.63 × E⁻³^†	2.11 × E⁻¹⁰^†
rs139389287	6	123818068	T	G	RP13–20L14.1	Household tobacco use	0.10	1.36 × E⁻³	0.02	0.73	3.35 × E⁻³	0.23	3.51 × E⁻⁸	0.02	0.78	2.11 × E⁻⁶
rs148834561^*	8	87300029	A	G	SLC7A13	Household drinking and illicit drug use	0.09	5.63 × E⁻³	—	—	—	0.26	4.71 × E⁻⁸	—	—	—
del-17:80342628	17	80342628	AG	A	TRDN	Change in residence	−0.04	6.47 × E⁻⁵	0.01	0.41	2.45 × E⁻³	−0.07	1.54 × E⁻⁸	0.01	0.73	6.36 × E⁻⁶
rs75591854^*	18	8814205	G	A	SOGA2	Household tobacco use	0.14	2.41 × E⁻⁴	—	—	—	0.25	3.91 × E⁻⁸	—	—	—
						Change in residence						0.27	4.34 × E⁻⁸	—	—	—
rs75414569^*	21	24128001	T	C	RN7SL609P	Household tobacco use	0.07	4.92 × E⁻⁵	—	—	—	0.14	9.73 × E⁻⁹	—	—	—
rs148009780^*	22	39775507	C	T	SYNGR1	Change in residence	0.10	2.05 × E⁻⁴	—	—	—	0.19	4.74 × E⁻⁸	—	—	—
Membership likelihood for subtype 4, European Americans
rs71428385	2	216288777	G	A	FN1	Household tobacco use	0.08	4.71 × E⁻³	−0.01	0.84	1.59 × E⁻⁵	0.23	3.99 × E⁻⁸	0.01	0.89	4.21 × E⁻⁵
rs56337958^*	4	183160533	A	G	TENM3	Traumatic experience	0.09	9.98 × E⁻⁴	—	—	—	0.31	3.07 × E⁻⁸	—	—	—

Alt = alternative allele; Chr = chromosome; Disc = discovery phase; Pos = base pair position; Ref = reference allele; Rep = replication phase.
↵* Polymorphism not included in the replication data set.
↵† Replicated genome-wide significant results.