Table 1

Clinical and demographic characteristics of nonresponders and responders to SCG DBS*

CharacteristicNonresponders (n = 12)Responders (n = 15)p value
Age, yr47.9 ± 7.746.6 ± 8.4NS
Male, n37NS
HRSD-17 baseline score25.2 ± 3.925.4 ± 3.7NS
Previous major depressive episodes, n3.9 ± 3.13.6 ± 2.8NS
Years since onset of MDD21.3 ± 9.618.1 ± 8.4NS
Duration of current major depressive episode, mo91.0 ± 56.353.5 ± 35.8NS
Trials of antidepressant medication before DBS, n4.2 ± 4.14.4 ± 3.6NS
Treated with ECT before DBS, n (%)5 (41.7)7 (46.7)NS
Treated with DBS during first major depressive episode, n (%)1 (8.3)1 (6.7)NS
Treated with antipsychotics at time of DBS, n (%)4 (33.3)5 (33.3)NS
Family history of MDD, n (%)6 (50.0)7 (46.7)NS
% improvement in HRSD-17 at 12 mo34.3 ± 18.369.2 ± 12.8< 0.001
  • DBS = deep brain stimulation; ECT = electroconvulsive therapy; HRSD-17 = Hamilton Rating Scale for Depression; MDD = major depressive disorder; NS = not significant; SCG = subcallosum cingulate gyrus; SD = standard deviation.

  • * All values expressed as mean ± SD, except where otherwise indicated. Significance threshold p < 0.05. Mann–Whitney test used to compare continuous variables, Fisher exact test used for dichotomous variables.