Sample characteristics
| Characteristic | Subtyping sample | GWAS sample | Replication sample | ||
|---|---|---|---|---|---|
| AA | EA | AA | EA | ||
| Total | 9965 | 2070 | 1570 | 918 | 1382 |
| Male, % | 53.81 | 59.42 | 60.76 | 66.78 | 67.58 |
| Age, mean ± SD | 40.14 ± 11.12 | 43.14 ± 7.76 | 37.69 ± 10.25 | 44.43 ± 9.14 | 38.07 ± 11.47 |
| Environmental factors, % | |||||
| Nontraditional parental care | — | 69.52 | 62.55 | 71.24 | 66.21 |
| Change in residence | — | 76.96 | 73.38 | 82.35 | 75.25 |
| Traumatic experience | — | 36.67 | 33.82 | 40.74 | 27.79 |
| Household drinking and illicit drug use | — | 61.88 | 58.54 | 62.85 | 56.51 |
| Household tobacco use | — | 74.59 | 81.40 | 75.71 | 75.33 |
| Cocaine use disorder traits, mean ± SD | |||||
| DSM-5 diagnostic criterion count | — | 8.10 ± 3.06 | 7.56 ± 3.79 | 7.46 ± 3.76 | 6.41 ± 4.37 |
| Membership likelihood for subtype 4 | — | 0.58 ± 0.40 | 0.32 ± 0.39 | 0.54 ± 0.42 | 0.28 ± 0.38 |
| Membership likelihood for subtype 5 | — | 0.18 ± 0.31 | 0.35 ± 0.42 | 0.16 ± 0.31 | 0.29 ± 0.40 |
AA = African American; EA = European American; GWAS = genome-wide association study; SD = standard deviation.