Table 2

Comparison of shapes between patients with bipolar disorder and healthy controls

Bundle	Df	Dim	Diagnosis		FA		Scanner		Age		Sex

			F₁	p value	F₁	p value	F₂	p value	F₁	p value	F₁	p value
Left AF	187	1	1.4	0.23	14.2	< 0.001^*	2.1	0.13	5.1	0.026	0.8	0.78
Left AF	187	2	15.1	< 0.001^*	24.5	< 0.001^*	1.9	0.16	3.5	0.06	0.3	0.61
Right AF	176	1	3.2	0.07	11.1	0.001^†	0.6	0.54	7.8	0.006^†	0.7	0.39
Right AF	176	2	0.1	0.84	1.3	0.24	4.4	0.014	0	0.96	0.7	0.39
Left CG	187	1	0.4	0.54	48.6	< 0.001^*	0.73	0.48	0	0.89	0.39	0.53
Left CG	187	2	4.99	0.027^†	0	0.87	2.5	0.08	0.8	0.37	0.3	0.56
Right CG	187	1	0.	0.91	32.4	< 0.001^*	8.3	< 0.001^†	0	0.99	0.8	0.91
Right CG	187	2	3.5	0.06	1.5	0.22	10.7	< 0.001^*	0.7	0.40	0	0.87
Left UN	187	1	4.4	0.036^†	30.3	< 0.001^*	26.1	< 0.001^*	4.9	0.029^†	2.8	0.10
Left UN	187	2	1.	0.31	0.5	0.48	7.7	< 0.001^†	3.0	0.08	1.7	0.20
Right UN	187	1	2.	0.16	3.0	0.08	39.7	< 0.001^*	10.2	0.002^†	0.3	0.57
Right UN	187	2	2.9	0.09	2.8	0.09	36.1	< 0.001^*	0	0.97	0.4	0.51

AF = arcuate fasciculus; CG = cingulum; Df = degrees of freedom; Dim = dimension; FA = fractional anisotropy; UN = uncinate fasciculus.
↵* Significant effect after Bonferroni correction for multiple tests (p < 4 × 10⁻⁴)
↵† Trend toward significance after Bonferroni correction for multiple tests (4 × 10⁻⁴ < p < 0.05).