Summary of results for Df(h22q11)/+ and other 22q11.2DS mouse models
| Model | Df(h22q11)/+ | Df(16)A+/− | LgDel | Df1/+ | |
|---|---|---|---|---|---|
| Deletion | Dgcr2-Hira | Dgcr2-Hira | Dgcr2-Hira | Dgcr14-Ufd11 | Znf74-Ctp |
| Strain | C57/Bl6N | C57/Bl6J | C57/Bl6N | Mixed C57/Bl6C-/C-; 129S5/SvEvBrd | 129SvEvTac or mixed 129SvEvTac |
| Phenotype; measure | |||||
| PPI | |||||
| Pre-puberty | ↓ | — | — | — | — |
| Post-puberty | ↓ | ↓ (18) | ↓ (16) | ↓ (17) | ↑ (15) |
| Clozapine or haloperidol challenges | x | — | — | — | — |
| Acoustic startle | |||||
| Pre-puberty | ↑ | — | — | — | — |
| Post-puberty | x( (17)) | ↑ (16) | ↑ (17) | x( (15)) | |
| Clozapine or haloperidol challenges | x | — | — | — | — |
| Stimulant LMA | |||||
| PCP | |||||
| Pre-puberty | x | — | — | — | — |
| Post-puberty | ↑ | — | — | — | — |
| Ketamine (post-puberty) | ↑ | — | — | — | — |
| Electrophysiology | |||||
| Prefrontal spike frequency | |||||
| Baseline | x | — | — | — | — |
| Gabazine challenge | x | — | — | — | — |
| Cortical low frequency oscillation | |||||
| Baseline | x | — | — | — | — |
| PCP challenge | x | — | — | — | — |
| LDAEP | ↑ | — | — | — | — |
| ABR | x | — | — | ↓ (19) | — |
| Biochemistry | |||||
| hPLC (PFC and DStr) | |||||
| DOPAC | ↑ | — | — | — | — |
| DA, 5-HT, NA, 5-HIAA, HVA | x | — | — | — | — |
| DStr microdialysis | — | — | — | — | |
| Baseline DA, DOPAC, Glu, HVA | x | — | — | — | — |
| Veratridine, nomifensine, PCP challenge | x | — | — | — | — |
| Western analysis (PFC, DStr, Hipp) | |||||
| Synaptic (PSD-95, SYP, Syn1, Drebrin, geophysin) | x | — | — | — | — |
| Cell type (NeuN, GFAP) | x | — | — | — | — |
| GABA (GABAAα1, KCC2, VGAT, GAD65/67) | x | — | — | — | — |
| Glutamate (GluR2, NR2A, NR2B, VGluT1) | x | — | — | — | — |
| DStr GluR1 | — | — | — | — | |
5-HIAA = 5-hydroxyindoleacetic acid; 5-HT = 5-hydroxytryptamine; ABR = auditory induced brainstem response; DA = dopamine; DOPAC = dihydroxyphenylacetic acid; DStr = dorsal striatum; GABA = γ-aminobutyric acid; Hipp = hippocampus; HVA = homovanillic acid; LDAEP = loudness dependence auditory evoked potentials; LMA = locomotor activity; NA = noradrenaline; PCP = phencyclidine; PFC = prefrontal cortex; PPI = prepulse inhibition; ↓ = decreased; ↑ = increased; x = no effect; () = did not replicate.